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Altered Insula Activity during Visceral Interoception in Weight-Restored Patients with Anorexia Nervosa
- Source :
- Neuropsychopharmacology. 41:521-528
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Anorexia nervosa (AN) is a devastating psychiatric illness that is associated with significant morbidity and mortality. Aberrant visceral interoceptive processing within the insula has been hypothesized to be an important mechanism in AN's pathophysiology due to the theoretical link between interoception and emotional experience. We therefore utilized functional magnetic resonance imaging (fMRI) to examine whether altered insula functioning underlies visceral interoception in AN. Fifteen females with restricting-type AN and 15 healthy control females underwent fMRI while performing an interoceptive attention task during which they focused on sensations in their heart, stomach, and bladder. Participants also performed an anxious rumination task while in the scanner. AN participants were weight-restored and free of psychotropic medications. Two distinct regions of the insula—anterior insula and dorsal mid-insula—exhibited a significant (p
- Subjects :
- medicine.medical_specialty
Anorexia Nervosa
Adolescent
Neuropsychological Tests
Audiology
behavioral disciplines and activities
Brain mapping
Body Mass Index
Young Adult
03 medical and health sciences
0302 clinical medicine
mental disorders
medicine
Humans
Attention
Psychiatry
Cerebral Cortex
Pharmacology
Brain Mapping
Proprioception
Magnetic Resonance Imaging
030227 psychiatry
Psychiatry and Mental health
Anorexia nervosa (differential diagnoses)
Rumination
Interoception
Anxiety
Female
Original Article
medicine.symptom
Psychology
Insula
psychological phenomena and processes
030217 neurology & neurosurgery
Psychopathology
Subjects
Details
- ISSN :
- 1740634X and 0893133X
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....161a4c4f28e2dd81a1bc8baddc0617b3