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The Ca2+ antagonist activity of lignans
- Source :
- Chemicalpharmaceutical bulletin. 34(8)
- Publication Year :
- 1986
-
Abstract
- A number of lignans, including those isolated from Arctium lappa (Compositae), were subjected to Ca2+ antagonist assay. The most potent activity occurred in trachelogenin, the calculated Ic50 and pA2 of which were 1.1×10-6 M and 6.60 respectively. Tranchelogenin had a potent and long-lasting antihypertensive effect on spontaneously hypertensive rats.
- Subjects :
- Lignan
Male
Plant Extracts
Guinea Pigs
Antagonist
Trachelogenin
Biological activity
Muscle, Smooth
General Chemistry
General Medicine
Pharmacology
Calcium Channel Blockers
Lignans
Rats
chemistry.chemical_compound
chemistry
Ca2 antagonist
Rats, Inbred SHR
Drug Discovery
Arctium lappa
Animals
IC50
Arctigenin
Antihypertensive Agents
Subjects
Details
- ISSN :
- 00092363
- Volume :
- 34
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Chemicalpharmaceutical bulletin
- Accession number :
- edsair.doi.dedup.....160a6f62a2f728327ecd43955956c86c