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Infectious background of patients with a history of acute anterior uveitis
- Source :
- University of Helsinki
- Publication Year :
- 2002
- Publisher :
- BMJ, 2002.
-
Abstract
- Objective: To study the infectious backround of patients with a history of acute anterior uveitis (AAU) and healthy control subjects. Methods: Sixty four patients with previous AAU and 64 sex and age matched controls were studied. Serum antibodies to Salmonellae , Yersiniae , Klebsiella pneumoniae , Escherichia coli , Proteus mirabilis , Campylobacter jejuni , and Borrelia burgdorferi were measured using enzyme linked immunosorbent assay (ELISA), and antibodies to Chlamydia trachomatis and Chlamydia pneumoniae by microimmunofluorescence test. Peripheral blood mononuclear cells (PBMCs), separated by density gradient centrifugation, were studied for Salmonella and Yersinia antigens by means of an immunofluorescence test, and for C pneumoniae DNA with a polymerase chain reaction (PCR). Results: Neither prevalence nor levels of single microbial antibodies studied differed between the patients and control subjects, or between subgroups of patients created on the basis of clinical characteristics. In logistic regression analysis, the high number of recurrences (>10) of AAU was independently related to the presence of single or multiple bacterial antibodies (p=0.04). None of the PBMC samples of the patients were positive for Yersinia or Salmonella antigens. C pneumoniae PCR was positive in a patient who was negative for C pneumoniae antibodies. Conclusion: Although neither the prevalence nor the levels of single microbial antibodies studied differed between the patients and the controls, current data suggest that the presence of single or multiple antibodies in patients with many recurrences of AAU compared with patients with none or few recurrences may be a sign of repeated infections, antigen persistence, or raised innate immune responsiveness.
- Subjects :
- Adult
Male
Klebsiella pneumoniae
Immunology
medicine.disease_cause
Immunofluorescence
General Biochemistry, Genetics and Molecular Biology
law.invention
03 medical and health sciences
0302 clinical medicine
Rheumatology
Antigen
Recurrence
law
medicine
Humans
Immunology and Allergy
Borrelia burgdorferi
HLA-B27 Antigen
Polymerase chain reaction
Aged
030203 arthritis & rheumatology
Antigens, Bacterial
Chlamydia
biology
medicine.diagnostic_test
business.industry
Bacterial Infections
Middle Aged
medicine.disease
biology.organism_classification
Antibodies, Bacterial
Uveitis, Anterior
3. Good health
Extended Report
Case-Control Studies
Acute Disease
030221 ophthalmology & optometry
biology.protein
Female
Antibody
business
Chlamydia trachomatis
Follow-Up Studies
Subjects
Details
- ISSN :
- 00034967
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Annals of the Rheumatic Diseases
- Accession number :
- edsair.doi.dedup.....1604d8dadc0d765cf22e7c0b9654d397