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Sensitization of Rh-negative daughters by their Rh-positive mothers
- Source :
- The New England journal of medicine. 276(10)
- Publication Year :
- 1967
-
Abstract
- THE prediction of immunologic tolerance by Burnett and Fenner1 suggested that tolerance to the Rh antigen might be induced in Rh-negative girls born of Rh-positive mothers.2 Immunologic tolerance was considered possible because maternal red cells cross the placenta to the fetus in at least some pregnancies.3 4 5 6 A contrary opinion held that the few authenticated cases of hemolytic disease, in first-born infants of mothers who had received no known stimulus, might be due to sensitization acquired by the mother in utero.7 , 8 This study was undertaken to determine whether Rh-positive mothers induce immunologic tolerance or primary sensitization in their Rh-negative daughters . . .
- Subjects :
- Adult
Male
Fetus
Rh-Hr Blood-Group System
business.industry
Pregnancy Complications, Hematologic
Infant, Newborn
General Medicine
Disease
Erythroblastosis, Fetal
medicine.anatomical_structure
Pregnancy
Placenta
Blood Group Incompatibility
Immunology
Antibody Formation
medicine
Immune Tolerance
Humans
Female
business
Immunologic Tolerance
Rh blood group system
Sensitization
Subjects
Details
- ISSN :
- 00284793
- Volume :
- 276
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- The New England journal of medicine
- Accession number :
- edsair.doi.dedup.....1604793e62a312e45093ab5efa145904