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Neuroprotective and Antioxidant Enhancing Properties of Selective Equisetum Extracts
- Source :
- Molecules, Vol 26, Iss 2565, p 2565 (2021), Molecules, Volume 26, Issue 9
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The sterile stems belonging to the Equisetum species are often used in traditional medicine of various nations, including Romanians. They are highly efficient in treating urinary tract infections, cardiovascular diseases, respiratory tract infections, and medical skin conditions due to their content of polyphenolic derivatives that have been isolated. In this regard, this study aimed to provide the chemical composition of the extracts obtained from the Equisetum species (E. pratense, E. sylvaticum, E. telmateia) and to investigate the biological action in vitro and in vivo. For the chemical characterization of the analyzed Equisetum species extracts, studies were performed by using ultra-high-performance liquid chromatography (UHPLC-DAD). In vitro evaluation of the antioxidant activity of the plant extracts obtained from these species of Equisetum genus was determined. The neuroprotective activity of these three ethanolic extracts from the Equisetum species using zebrafish tests was determined in vivo. All obtained results were statistically significant. The results indicate that E. sylvaticum extract has a significant antioxidant activity<br />whereas, E. pratense extract had anxiolytic and antidepressant effects significantly higher than the other two extracts used. All these determinations indicate promising results for the antioxidant in vitro tests and neuroprotective activity of in vivo tests, particularly mediated by their active principles.
- Subjects :
- Equisetum telmateia
Antioxidant
medicine.medical_treatment
Pharmaceutical Science
antioxidant activity
Organic chemistry
Analytical Chemistry
03 medical and health sciences
0302 clinical medicine
QD241-441
In vivo
Equisetum pratense
Drug Discovery
UHPLC
medicine
polyphenolic derivatives
Equisetum
Physical and Theoretical Chemistry
030304 developmental biology
0303 health sciences
Traditional medicine
biology
Chemistry
neuroprotective
biology.organism_classification
In vitro
Chemistry (miscellaneous)
Polyphenol
Equisetum sylvaticum
Molecular Medicine
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 2565
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....15f4d305574f7b1502ab8e747f35c28b