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ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology
- Source :
- Parasite immunology. 27(4)
- Publication Year :
- 2005
-
Abstract
- ES-62, a filarial nematode-derived anti-inflammatory immunomodulator, was administered to mice in an attempt to prevent pathology associated with Toxoplasma gondii infection. The nematode product was shown to elevate mitogen and T. gondii-specific IL-10 production but was unable to inhibit Th1 responses. Consequently ES-62 could not prevent Th1 generated immunopathology.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Immunology
Lung pathology
Mice
Immunopathology
parasitic diseases
medicine
Animals
Immunologic Factors
Lung
Mice, Inbred BALB C
biology
Extramural
Toxoplasma gondii
Brain
Helminth Proteins
Th1 Cells
biology.organism_classification
medicine.disease
Toxoplasmosis
Interleukin-10
Intestines
Mice, Inbred C57BL
Disease Models, Animal
Toxoplasmosis, Animal
Liver
Cytokines
Parasitology
Th1 response
Liver pathology
Toxoplasma
Subjects
Details
- ISSN :
- 01419838
- Volume :
- 27
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Parasite immunology
- Accession number :
- edsair.doi.dedup.....15f462ddecffab319ebd7786ec777b30