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Intermittent pacing therapy favorably modulates infarct remodeling
- Source :
- Basic Research in Cardiology, 112(3):28. D. Steinkopff-Verlag, Basic Research in Cardiology, 112(3):28. Springer, Basic Research in Cardiology
- Publication Year :
- 2017
- Publisher :
- Springer, 2017.
-
Abstract
- Despite early revascularization, remodeling and dysfunction of the left ventricle (LV) after acute myocardial infarction (AMI) remain important therapeutic targets. Intermittent pacing therapy (IPT) of the LV can limit infarct size, when applied during early reperfusion. However, the effects of IPT on post-AMI LV remodeling and infarct healing are unknown. We therefore investigated the effects of IPT on global LV remodeling and infarct geometry in swine with a 3-day old AMI. For this purpose, fifteen pigs underwent 2 h ligation of the left circumflex coronary artery followed by reperfusion. An epicardial pacing lead was implanted in the peri-infarct zone. After three days, global LV remodeling and infarct geometry were assessed using magnetic resonance imaging (MRI). Animals were stratified into MI control and IPT groups. Thirty-five days post-AMI, follow-up MRI was obtained and myofibroblast content, markers of extracellular matrix (ECM) turnover and Wnt/frizzled signaling in infarct and non-infarct control tissue were studied. Results showed that IPT had no significant effect on global LV remodeling, function or infarct mass, but modulated infarct healing. In MI control pigs, infarct mass reduction was principally due to a 26.2 ± 4.4% reduction in infarct thickness (P ≤ 0.05), whereas in IPT pigs it was mainly due to a 35.7 ± 4.5% decrease in the number of infarct segments (P ≤ 0.05), with no significant change in infarct thickness. Myofibroblast content of the infarct zone was higher in IPT (10.9 ± 2.1%) compared to MI control (5.4 ± 1.6%; P ≤ 0.05). Higher myofibroblast presence did not coincide with alterations in expression of genes involved in ECM turnover or Wnt/frizzled signaling at 5 weeks follow-up. Taken together, IPT limited infarct expansion and altered infarct composition, showing that IPT influences remodeling of the infarct zone, likely by increasing regional myofibroblast content. Electronic supplementary material The online version of this article (doi:10.1007/s00395-017-0616-3) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
0301 basic medicine
Physiology
Swine
medicine.medical_treatment
PRECONDITIONS RABBIT MYOCARDIUM
030204 cardiovascular system & hematology
Polymerase Chain Reaction
Coronary artery disease
Random Allocation
0302 clinical medicine
Myocardial infarction
REPERFUSION INJURY
Myofibroblasts
Ventricular Remodeling
Cardiac Pacing, Artificial
Original Contribution
CARDIAC FIBROBLASTS
EXPANSION
Magnetic Resonance Imaging
medicine.anatomical_structure
TARGET
cardiovascular system
Cardiology
Infarct expansion
CORONARY-ARTERY-DISEASE
HEART-FAILURE
Female
Infarct geometry
Cardiology and Cardiovascular Medicine
Myofibroblast
medicine.medical_specialty
Revascularization
03 medical and health sciences
Physiology (medical)
Internal medicine
parasitic diseases
medicine
Animals
cardiovascular diseases
business.industry
medicine.disease
Disease Models, Animal
030104 developmental biology
SIZE
Ventricle
TISSUE
Heart failure
Infarct healing
Ligation
business
Reperfusion injury
Subjects
Details
- Language :
- English
- ISSN :
- 03008428
- Volume :
- 112
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Basic Research in Cardiology
- Accession number :
- edsair.doi.dedup.....15e93772eea79bdedbc0749ab3f72686