Supplementary Figures and Legends from USP8 Is a Novel Target for Overcoming Gefitinib Resistance in Lung Cancer

Supplementary Figures and Legends - PDF file 2854K, Supplementary Figure 1. Effect of USP8 knockdown on cell viability Supplementary Figure 2. Effect of USP8 knockdown on EGFR wildtype cells and apoptosis of NSCLC and normal cells. Supplementary Figure 3. Effect of USP8 knockdown on mRNA levels of RTKs. Supplementary Figure 4. Effect of USP8 inhibitor treatment on apoptosis of NSCLC and normal cells. Supplementary Figure 5. Fluorescence Intensity Profiling Supplementary Figure 6. Effect of USP8 knockdown or an USP8 inhibitor on insulin receptor (IR) expression. Supplementary Figure 7. An USP8 inhibitor reduces ERKs and STAT3 phosphorylation levels in tumors