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Immunohistochemical studies of selected skin diseases and tumors using monoclonal antibodies to neurofilament and myelin proteins
- Source :
- Journal of the American Academy of Dermatology. 13(1)
- Publication Year :
- 1985
-
Abstract
- Several skin diseases and tumors were immunohistochemically studied with the use of monoclonal antibodies against myelin proteins and neurofilament proteins. In prurigo nodularis, many nerve fibers were found embedded in dense inflammatory cell infiltration. Abnormal innervation was observed in piloleiomyoma. The axons were demonstrated within the cytoplasm of granular cells of granular cell schwannoma. In neurofibroma, tumor cells had myelin proteins in their cytoplasms. Many cells and fibers that contained myelin proteins were demonstrated in nevus cell nevus, especially in compound nevus and intradermal nevus, and it was suggested that schwannian cells may be the origin of some nevus cells.
- Subjects :
- Pathology
medicine.medical_specialty
Neurofilament
Skin Neoplasms
medicine.drug_class
Dermatology
Schwannoma
Biology
Monoclonal antibody
Skin Diseases
Immunoenzyme Techniques
Myelin
Nerve Fibers
Intermediate Filament Proteins
Neurofilament Proteins
medicine
Intradermal Nevus
Neurofibroma
Nevus
Humans
skin and connective tissue diseases
Skin
Nevus, Pigmented
Antibodies, Monoclonal
Compound nevus
medicine.disease
medicine.anatomical_structure
nervous system
Prurigo
Myelin Proteins
Neurilemmoma
Subjects
Details
- ISSN :
- 01909622
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of the American Academy of Dermatology
- Accession number :
- edsair.doi.dedup.....15e05c0ae45b8f22ceeea701ac02e7cd