TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures

Authors :: Ricardo A. Chaurio
Carmen M. Anadon
Tara Lee Costich
Kyle K. Payne
Subir Biswas
Carly M. Harro
Carlos Moran
Antonio C. Ortiz
Carla Cortina
Kristen E. Rigolizzo
Kimberly B. Sprenger
Jessica A. Mine
Patrick Innamarato
Gunjan Mandal
John J. Powers
Alexandra Martin
Zhitao Wang
Sumit Mehta
Bradford A. Perez
Roger Li
John Robinson
Jodi L. Kroeger
Tyler J. Curiel
Xiaoqing Yu
Paulo C. Rodriguez
Jose R. Conejo-Garcia
Source :: Immunity. 55:115-128.e9
Publication Year :: 2022
Publisher :: Elsevier BV, 2022.
Abstract: The immune checkpoint receptor PD-1 on T follicular helper (Tfh) cells promotes Tfh:B cell interactions and appropriate positioning within tissues. Here, we examined the impact of regulation of PD-1 expression by the genomic organizer SATB1 on Tfh cell differentiation. Vaccination of CD4

Subjects :: Mice, Knockout
Genotype
Programmed Cell Death 1 Receptor
Immunology
Cell Differentiation
Matrix Attachment Region Binding Proteins
T-Lymphocytes, Helper-Inducer
Germinal Center
Mice, Inbred C57BL
Mice
Lymphocytes, Tumor-Infiltrating
Tertiary Lymphoid Structures
Infectious Diseases
Gene Expression Regulation
Transforming Growth Factor beta
Animals
Immunology and Allergy
Gene Silencing

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