Back to Search
Start Over
Dose adjustment for tyrosine kinase inhibitors in non-small cell lung cancer patients with hepatic or renal function impairment
- Source :
- Oncology Reports
- Publication Year :
- 2020
- Publisher :
- D.A. Spandidos, 2020.
-
Abstract
- In recent years, a number of tyrosine kinase inhibitors (TKIs) have been approved for the treatment of non‑small cell lung cancer. These novel treatments exhibit improved efficacy and toxicity when compared to conventional chemotherapy agents. TKIs are administered orally, which has the advantages of improved flexibility and convenience for the patients. However, challenges have arisen in the use of these novel agents. Prescribing drugs for patients with hepatic or renal function impairment poses a challenge for clinicians due to the large pharmacokinetic variability in each individual patient. Moreover, several TKIs have been shown to cause laboratory test abnormalities normally associated with hepatic or renal injury. The aim of the present review was to discuss the effects of hepatic and renal function impairment on the pharmacokinetic variability of 17 TKIs and their potential hepatotoxicity and nephrotoxicity, and to recommend dose adjustment for patients with hepatic or renal impairment.
- Subjects :
- 0301 basic medicine
Oncology
renal impairment
Cancer Research
medicine.medical_specialty
Lung Neoplasms
hepatic impairment
Renal function
Antineoplastic Agents
Review
Kidney
Nephrotoxicity
03 medical and health sciences
0302 clinical medicine
Pharmacokinetics
Carcinoma, Non-Small-Cell Lung
Internal medicine
tyrosine kinase inhibitors
medicine
dose adjustment
Humans
Drug Dosage Calculations
Renal Insufficiency
Lung cancer
Protein Kinase Inhibitors
non-small cell lung cancer
Dose-Response Relationship, Drug
business.industry
Cancer
General Medicine
medicine.disease
Molecular medicine
respiratory tract diseases
Hepatobiliary Elimination
Renal Elimination
030104 developmental biology
Biological Variation, Population
Liver
030220 oncology & carcinogenesis
Toxicity
business
Tyrosine kinase
Liver Failure
Subjects
Details
- Language :
- English
- ISSN :
- 17912431 and 1021335X
- Volume :
- 45
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Oncology Reports
- Accession number :
- edsair.doi.dedup.....15d3d81b2ebfd40ea7347c53723e29e0