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Unusual dermatological toxicity of hydroxyurea in two dogs with spontaneously occurring tumours
- Source :
- Journal of Small Animal Practice. 48:514-517
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Hydroxyurea is a chemotherapeutic agent used to treat hypereosinophilic syndrome, mast cell tumours and many myeloproliferative disorders. It is usually well tolerated; however, reported side effects include myelosuppression and gastrointestinal complications as well as cutaneous toxicity, in very rare cases. We report the unusual appearance of onychomadesis involving several claws on all feet in two canine patients receiving long-term hydroxyurea treatment. The healing of nail lesions required cessation of treatment in one dog and dose reduction in the second animal, supporting a strict relationship between onychopathy and administration of hydroxyurea. The aim of this case report is to increase clinical awareness of dermatological toxicity associated with long-term administration of hydroxyurea.
- Subjects :
- Male
Hoof and Claw
Pathology
medicine.medical_specialty
Time Factors
Antineoplastic Agents
Onychomadesis
Antineoplastic Agent
Foot Diseases
Gastrointestinal complications
Dogs
Myeloproliferative Disorders
Dog
Animals
Hydroxyurea
Medicine
Dog Diseases
Small Animals
Animal
business.industry
Hypereosinophilic syndrome
Mast cell
medicine.disease
Dermatology
medicine.anatomical_structure
Foot Disease
Toxicity
Nail (anatomy)
Female
Dose reduction
Dog Disease
business
Subjects
Details
- ISSN :
- 17485827 and 00224510
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Journal of Small Animal Practice
- Accession number :
- edsair.doi.dedup.....15d127beefdbad4172df6b80b2fac855