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Increasing rates of quinolone-resistant Neisseria gonorrhoeae in Paris, France
- Source :
- Journal of the European Academy of Dermatology and Venereology. 21:818-821
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Quinolone-resistant Neisseria gonorrhoeae (QRNG) rates are increasing worldwide.(i) To assess the rate of QRNG among patients referred to a venereology clinic in Paris between 2000 and 2004; and (ii) to assess associated epidemiological factors.Retrospective study of consecutive cases over 2000-2004. Indications and techniques of swabbing and culture were constant over 2000-2004. Susceptibility of N. gonorrhoeae was tested to six antibiotics: ciprofloxacin, amoxicillin, cefotaxime, tetracycline, erythromycin, and spectinomycin. Epidemiological data and anatomical site of N. gonorrhoeae infection were collected.Annual numbers of cases decreased (P10(-4)) from 2000 (n = 41) to 2002 (n = 12), then increased (P10(-4)) in 2004 (n = 60). Anorectal gonorrhoea was more frequent in 2003-2004 (22.0%, n = 18/82) than in 2000-2002 (3.9%, n = 3/76). QRNG rates increased from the period 2000-2002 (1.3%) to 2003 (22.7%, P0.01), and 2004 (30.2%, P0.005). All QRNG strains had a minimal inhibitory concentration of ciprofloxacin1.0 mg/L, thus fitting the international definition of quinolone resistance. There were no significant changes in rates of N. gonorrhoeae resistance to the five other antibiotics. QRNG tended to be more frequent among men who have sex with men (MSM; 16.7% vs. 7.1%), HIV-infected patient (20.5% vs. 11.9%), and patients having more than five partners during the last year (24.4% vs. 17.1%), but statistical significance was not reached in multivariate analyses.We recommend (i) avoiding fluoroquinolones as first-line treatment for N. gonorrhoeae infections in Paris; (ii) that first-line treatment relies on third-generation cephalosporins or spectinomycin; and (iii) reinforcing targeted screening and prevention of gonorrhoea, especially among HIV-positive patients and MSM.
- Subjects :
- Adult
Male
Paris
medicine.medical_specialty
Cefotaxime
Spectinomycin
Adolescent
Erythromycin
Microbial Sensitivity Tests
Dermatology
Drug resistance
medicine.disease_cause
Microbiology
Gonorrhea
Antibiotic resistance
Risk Factors
Internal medicine
Drug Resistance, Bacterial
medicine
Humans
Aged
Retrospective Studies
business.industry
Incidence
Middle Aged
Amoxicillin
Neisseria gonorrhoeae
Ciprofloxacin
Infectious Diseases
Female
business
Fluoroquinolones
medicine.drug
Subjects
Details
- ISSN :
- 14683083 and 09269959
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Journal of the European Academy of Dermatology and Venereology
- Accession number :
- edsair.doi.dedup.....15d12716ae48e572e2ac6dff96f02fb7