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Type III Protein Secretion Is Associated with Death in Lower Respiratory and SystemicPseudomonas aeruginosaInfections
- Source :
- The Journal of Infectious Diseases. 183:1767-1774
- Publication Year :
- 2001
- Publisher :
- Oxford University Press (OUP), 2001.
-
Abstract
- The ability of Pseudomonas aeruginosa to secrete specific toxins using the type III-mediated pathway has been reported. To determine the association of this phenotype with human illness, immunoblot analysis was used to detect expression of type III secretory proteins in P. aeruginosa isolates from respiratory tract or blood cultures of 108 consecutive patients. Relative risk of mortality was 6-fold greater with expression of the type III secretory proteins ExoS, ExoT, ExoU, or PcrV. Phenotype was independently correlated with toxicity in cellular and murine models. Prevalence of this phenotype was significantly higher in acutely infected patients than in chronically infected patients with cystic fibrosis. These results suggest that the type III protein secretion system is integral to increased P. aeruginosa virulence. A positive phenotype is a predictor of poor clinical outcome. In the future, such analyses may help distinguish potentially lethal infection from colonization and help determine appropriate therapy for critically ill patients.
- Subjects :
- Adult
Male
Adolescent
Cystic Fibrosis
Immunoblotting
Virulence
Biology
medicine.disease_cause
Cystic fibrosis
Microbiology
Bacterial Proteins
Prevalence
medicine
Humans
Immunology and Allergy
Pseudomonas Infections
Secretion
Child
Respiratory Tract Infections
Aged
Aged, 80 and over
Pseudomonas aeruginosa
Respiratory disease
Infant, Newborn
Infant
Middle Aged
medicine.disease
Phenotype
Infectious Diseases
medicine.anatomical_structure
Secretory protein
Child, Preschool
Acute Disease
Chronic Disease
Immunology
Female
Biomarkers
Respiratory tract
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 183
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....15cec5a9e441ce893ce968677f1c2a12