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Aggressive and frequent resection of recurrences in retroperitoneal sarcoma contributes to long-term survival
- Source :
- Langenbeck's archives of surgery. 406(5)
- Publication Year :
- 2020
-
Abstract
- Retroperitoneal sarcoma (RPS) is a rare tumor with a poor prognosis and is often undetected until it is significantly enlarged. While surgical resection remains the primary treatment, there is little research on its benefits, especially that concerning the reoperation of recurrent disease. This study investigated the impact of surgical procedures, especially reoperation of recurrent RPS, on prognosis. This retrospective study included 51 patients who underwent radical resection surgery (R0 status) for primary or recurrent RPS without distant metastasis. Patient outcomes and prognosis were defined in terms of the clinicopathologic factors and surgical techniques performed. In all cases, the 5-year disease-free survival (DFS) rate was 28.2%, 5-year overall survival rate was 89.9%, and 5-year no residual liposarcoma rate was 54.3% after operation and re-reoperation. There was a statistically significant difference between the 5-year DFS rate and 5-year no residual liposarcoma rate due to frequent re-reoperation (p = 0.011). On univariate analysis of primary and recurrent lesions, the histological type and the number of organs involved were identified as statistically significant prognostic factors. Patients with well-differentiated liposarcomas had a statistically better prognosis than those with other cancer types (primary RPS, p = 0.028; recurrence, p = 0.024). Aggressive and frequent resection of recurrent RPS with combined resection of adjacent organs contributes to long-term survival. The establishment of a surgical strategy for RPS will require a prospective study.
- Subjects :
- medicine.medical_specialty
Liposarcoma
Metastasis
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Prospective Studies
Retroperitoneal Neoplasms
Prospective cohort study
Retrospective Studies
Univariate analysis
business.industry
Cancer
Retrospective cohort study
Sarcoma
Vascular surgery
medicine.disease
Prognosis
Surgery
Survival Rate
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Neoplasm Recurrence, Local
business
Abdominal surgery
Subjects
Details
- ISSN :
- 14352451
- Volume :
- 406
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Langenbeck's archives of surgery
- Accession number :
- edsair.doi.dedup.....15caeb91a0bc01716fc8a4a7db668655