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Modular phosphoinositide-binding domains – their role in signalling and membrane trafficking
- Source :
- Current Biology. 11:R882-R893
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- The membrane phospholipid phosphatidylinositol is the precursor of a family of lipid second-messengers, known as phosphoinositides, which differ in the phosphorylation status of their inositol group. A major advance in understanding phosphoinositide signalling has been the identification of a number of highly conserved modular protein domains whose function appears to be to bind various phosphoinositides. Such ‘cut and paste’ modules are found in a diverse array of multidomain proteins and recruit their host protein to specific regions in cells via interactions with phosphoinositides. Here, with particular reference to proteins involved in membrane traffic pathways, we discuss recent advances in our understanding of phosphoinositide-binding domains.
- Subjects :
- Phosphatidylinositol 4,5-Diphosphate
Vesicle-associated membrane protein 8
Protein domain
Biology
Phosphatidylinositols
Second Messenger Systems
General Biochemistry, Genetics and Molecular Biology
Conserved sequence
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Protein structure
Phagocytosis
Phosphatidylinositol Phosphates
Amino Acid Sequence
Phosphatidylinositol
Binding site
Conserved Sequence
030304 developmental biology
0303 health sciences
Binding Sites
Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Blood Proteins
Phosphoproteins
Endocytosis
Protein Structure, Tertiary
Cell biology
chemistry
Biochemistry
Second messenger system
Phosphorylation
General Agricultural and Biological Sciences
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 09609822
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Current Biology
- Accession number :
- edsair.doi.dedup.....15c1b859eb186e4bdb052ece6198ff3d