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Clinical Outcomes of Chemotherapy for Diabetic and Nondiabetic Patients With Pancreatic Cancer
- Source :
- Pancreas. 42:202-208
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- The aim of this study was to clarify the impact of diabetes mellitus (DM) as well as antidiabetic, antihypertensive, and antihyperlipidemic medications such as metformin and statins on survival in patients with advanced pancreatic cancer receiving chemotherapy.We retrospectively reviewed the medical records of 250 patients with advanced pancreatic cancer receiving chemotherapy. Multivariate analyses of prognostic factors for survival were performed both in overall population and in subgroups with and without DM.Diabetes mellitus was diagnosed in 124 patients (50%) who had less distant metastasis and more hypertension. Thirty patients received statin for hyperlipidemia. Overall survival was 13.3 versus 10.0 months with and without DM (P = 0.084), but hazard ratio of DM was 1.05 (P = 0.758) in the multivariate analysis. Subgroup analysis of diabetic patients, but not in non-diabetic patients, demonstrated use of statins (hazard ratio, 0.40; P = 0.010) as a prognostic factor, as well as distant metastasis, performance status, combination therapy with gemcitabine and S-1, and use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. No antidiabetic medications were prognostic factors.Neither DM nor antidiabetic treatment had prognostic impact on advanced pancreatic cancer. Statin use was associated with better survival in the diabetic patients.
- Subjects :
- Male
Time Factors
endocrine system diseases
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Comorbidity
Kaplan-Meier Estimate
Deoxycytidine
Endocrinology
Japan
Risk Factors
Antineoplastic Combined Chemotherapy Protocols
Aged, 80 and over
Middle Aged
Metformin
Drug Combinations
Treatment Outcome
Hypertension
Female
medicine.drug
Adult
medicine.medical_specialty
Hyperlipidemias
Disease-Free Survival
Pancreatic cancer
Diabetes mellitus
Internal medicine
Diabetes Mellitus
Internal Medicine
medicine
Humans
Hypoglycemic Agents
Antihypertensive Agents
Aged
Retrospective Studies
Tegafur
Chemotherapy
Chi-Square Distribution
Hepatology
business.industry
nutritional and metabolic diseases
Retrospective cohort study
Statin treatment
medicine.disease
Gemcitabine
Surgery
Pancreatic Neoplasms
Oxonic Acid
Multivariate Analysis
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Chi-squared distribution
Subjects
Details
- ISSN :
- 08853177
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.doi.dedup.....15be618ea52a6061b6e25e2ce0fee171