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Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil
- Source :
- Cancer Chemotherapy and Pharmacology. 18
- Publication Year :
- 1986
- Publisher :
- Springer Science and Business Media LLC, 1986.
-
Abstract
- The folate analogue 5,8-dideazaisopteroylglutamate (IAHQ; NSC-289517) inhibits the growth of a variety of human tumor cells in vitro such as colon, breast and osteosarcoma. Since IAHQ has only modest activity against L1210 leukemia in mice, it was tested in combination with methotrexate (MTX), probenecid, or verapamil in an effort to enhance efficacy. Single drug or drug combinations were administered every other day 3 or 5 times beginning on day 1 following the administration of 10(6) L1210 cells per animal. The combination of IAHQ (100 mg/kg) plus MTX (10 mg/kg) produced a decrease in mean survival time compared to that of MTX alone, regardless of whether the drugs were initiated on the same day or whether either one was started 2 days prior to the other. IAHQ (150 mg/kg) plus verapamil (5, 10, or 20 mg/kg) did not alter significantly the results produced by IAHQ alone. However, the combination of IAHQ (150 mg/kg) plus probenecid (250 mg/kg) augmented the increase in mean survival time above that produced by IAHQ alone by 82% (p = less than 0.001). The results suggest that probenecid could be used to enhance the effectiveness of IAHQ against solid tumors such as colon adenocarcinoma.
- Subjects :
- Male
Drug
Cancer Research
Time Factors
Ratón
media_common.quotation_subject
medicine.medical_treatment
Pharmacology
Toxicology
Mice
Antineoplastic Combined Chemotherapy Protocols
medicine
Animals
Pharmacology (medical)
Leukemia L1210
media_common
Chemotherapy
Probenecid
business.industry
In vitro
Methotrexate
Verapamil
Oncology
Mice, Inbred DBA
Quinazolines
Folic Acid Antagonists
L1210 cells
business
medicine.drug
Subjects
Details
- ISSN :
- 14320843 and 03445704
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Cancer Chemotherapy and Pharmacology
- Accession number :
- edsair.doi.dedup.....15b3a0b6666fa2fef748d34ccb0bf379