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Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-α
- Source :
- Genetics and Molecular Research. 13:10909-10912
- Publication Year :
- 2014
- Publisher :
- Genetics and Molecular Research, 2014.
-
Abstract
- TNF 308 gene polymorphism and IL-10 polymorphism provided evidence in diagnosing some types of cancer. We aimed to explore the relation of gene polymorphism with gastric cancer. A total of 360 cases of gastric cancer patients were included in the study. The genotypes GG, GA, and AA of the interleukin-10-1082 gene (IL-10-1082) and the tumor necrosis factor-alpha gene (TNF-α) 308 polymorphism were examined by chromogenic detection. Three hundred healthy individuals' gene as control group were also examined. The GA 308 genotype of TNF-α differed significantly between the control group and the gastric cancer group (c 2 = 9.32, P < 0.05). Genotype frequencies of A/A (17.2%), A/G (26.2%), and G/G (9.1%) of the IL-10-1082 gene polymorphism in the gastric cancer group differed significantly compared to those of the control group ( c 2 = 20.32, P < 0.05). The IL-10-1082 gene and the GA 308 genotype of the TNF-α gene were found to be susceptibility genes for gastric cancer.
- Subjects :
- Adult
Male
China
medicine.medical_specialty
Genotype
Biology
Bioinformatics
Gastroenterology
Clinical study
Asian People
Stomach Neoplasms
Internal medicine
Genetics
medicine
Humans
Genetic Predisposition to Disease
Molecular Biology
Gene
Genetic Association Studies
Aged
Polymorphism, Genetic
Tumor Necrosis Factor-alpha
Cancer susceptibility
General Medicine
Middle Aged
Interleukin-10
Genotype frequency
Interleukin 10
Case-Control Studies
Female
Tumor necrosis factor alpha
Gene polymorphism
Subjects
Details
- ISSN :
- 16765680
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Genetics and Molecular Research
- Accession number :
- edsair.doi.dedup.....15a8440abe216480b78878b7533a667f