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Ferroptosis-Related Long Non-Coding RNA signature predicts the prognosis of Head and neck squamous cell carcinoma
- Source :
- International Journal of Biological Sciences
- Publication Year :
- 2020
-
Abstract
- Background: Head and neck squamous cell carcinoma (HNSCC) are head and neck cancers. On the other hand, ferroptosis is a novel iron-dependent and ROS reliant type of cell death observed various disease conditions. Method: We constructed a prognostic multilncRNA signature based on ferroptosis-related differentially expressed lncRNAs in HNSCC. Results: We identified 25 differently expressed lncRNAs associated with prognosis of HNSCC. Kaplan-Meier analyses revealed the high-risk lncRNAs signature associated with poor prognosis of HNSCC. Moreover, the AUC of the lncRNAs signature was 0.782, underscoring their utility in prediction HNSCC prognosis. Indeed, our risk assessment model was superior to traditional clinicopathological features in predicting HNSCC prognosis. GSEA revealed the immune and tumor-related pathways in the low risk group individuals. Moreover, TCGA revealed T cell functions including cytolytic activity, HLA, regulation of inflammationp, co-stimulation, co-inhibition and coordination of type II INF response were significantly different between the low-risk and high-risk groups. Immune checkpoints such as PDCD-1 (PD-1), CTLA4 and LAG3, were also expressed differently between the two risk groups. Conclusion: A novel ferroptosis-related lncRNAs signature impacts on the prognosis of HNSCC.
- Subjects :
- Male
LAG3
T cell
lncRNAs
Disease
Human leukocyte antigen
Applied Microbiology and Biotechnology
03 medical and health sciences
Immune system
medicine
Humans
genes
data mining
Molecular Biology
Gene
Ecology, Evolution, Behavior and Systematics
030304 developmental biology
Aged
0303 health sciences
business.industry
immune infiltration
Gene Expression Profiling
Head and neck squamous cell carcinoma
Cell Biology
Middle Aged
medicine.disease
Head and neck squamous-cell carcinoma
Long non-coding RNA
ferroptosis
stomatognathic diseases
Nomograms
medicine.anatomical_structure
Head and Neck Neoplasms
Case-Control Studies
Cancer research
Carcinoma, Squamous Cell
Female
RNA, Long Noncoding
business
Developmental Biology
Research Paper
Subjects
Details
- ISSN :
- 14492288
- Volume :
- 17
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- International journal of biological sciences
- Accession number :
- edsair.doi.dedup.....159cd7e4843e35cb6faa0c88d0dc3ee3