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Characteristics of blood chemistry, hematology, and lymphocyte subsets in pregnant rhesus monkeys
- Source :
- Chinese journal of natural medicines. 13(6)
- Publication Year :
- 2014
-
Abstract
- The present study was designed to characterize the blood chemistry, hematology, and lymphocyte subsets in pregnant rhesus monkeys and provide baseline parameters for future studies of reproductive and developmental toxicity and developmental immunotoxicity. Harem-mating was used in 96 female and 16 male rhesus monkeys. Pregnancy was confirmed on gestation day (GD)18 by ultrasound. The blood samples of rhesus monkeys were collected at various times (20 days before pregnancy and GD20, 100 and 150). The analyses of blood chemistry, hematology, and lymphocyte subsets were performed. Compared with 20 days before pregnancy, Significant decreases (P0.05) were observed in HCT and RBC on GD20, GD150 and in HGB on GD150, Significant increases in NEUT and decreases in LYMPH on GD20 were observed. Significant decreases in ALB from GD20 to GD150 were observed, significant decreases in TP was observed on GD100. Significant increases in mean GLU were observed on GD20 and GD150 during pregnancy. Significant decreases (P0.05) in CD20(+) subsets on GD100, GD150 and CD4(+)/CD8(+)ratio on GD150 were observed, The significant changes of MCV, MCHC, RDW-SD, MCV, MONO, ALT, AST, GLB, ALP, TBIL, DBIL, IBIL, GGT, CR-S, URIC, TC, TG and CK were observed during the pregnant period, but no biologic change were observed, There were no significant changes in MCH, RDW-CV, MPV, BUN, CD3(+), CD4(+) and CD8(+) during pregnancy. These data provide a database for preclinical study in rhesus monkeys. Physiological anemia, hyperglycemia, and immune suppression may occur in pregnant rhesus monkey which is similar to that found in human, and it is essential to distinguish the physiological changes from the pharmacological effects in reproductive and developmental toxicity and developmental immunotoxicity studies of pharmaceuticals.
- Subjects :
- Male
medicine.medical_specialty
Anemia
Developmental toxicity
Biology
Immune system
Pregnancy
Internal medicine
Drug Discovery
medicine
Animals
Humans
Hematology
Reproduction
General Medicine
medicine.disease
Macaca mulatta
Lymphocyte Subsets
Endocrinology
Complementary and alternative medicine
Blood chemistry
Models, Animal
Gestation
Female
TBIL
Blood Chemical Analysis
Subjects
Details
- ISSN :
- 18755364
- Volume :
- 13
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Chinese journal of natural medicines
- Accession number :
- edsair.doi.dedup.....1585684320e765cfa48233b65ae6c8e9