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Colonized Sabethes cyaneus, a Sylvatic New World Mosquito Species, Shows a Low Vector Competence for Zika Virus Relative to Aedes aegypti
- Source :
- Viruses, Vol 10, Iss 8, p 434 (2018), Viruses, Volume 10, Issue 8
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- The introduction of Zika virus (ZIKV) to the Americas raised concern that the virus would spill back from human transmission, perpetuated by Aedes aegypti, into a sylvatic cycle maintained in wildlife and forest-living mosquitoes. In the Americas, Sabethes species are vectors of sylvatic yellow fever virus (YFV) and are therefore candidate vectors of a sylvatic ZIKV cycle. To test the potential of Sabethes cyaneus to transmit ZIKV, Sa. cyaneus and Ae. aegypti were fed on A129 mice one or two days post-infection (dpi) with a ZIKV isolate from Mexico. Sa. cyaneus were sampled at 3, 4, 5, 7, 14, and 21 days post-feeding (dpf) and Ae. aegypti were sampled at 14 and 21 dpf. ZIKV was quantified in mosquito bodies, legs, and saliva to measure infection, dissemination, and potential transmission, respectively. Of 69 Sa. cyaneus that fed, ZIKV was detected in only one, in all body compartments, at 21 dpf. In contrast, at 14 dpf 100% of 20 Ae. aegypti that fed on mice at 2 dpi were infected and 70% had virus in saliva. These data demonstrate that Sa. cyaneus is a competent vector for ZIKV, albeit much less competent than Ae. aegypti.
- Subjects :
- Aedes aegypti
0301 basic medicine
animal structures
030231 tropical medicine
lcsh:QR1-502
Animals, Wild
Mosquito Vectors
Article
Virus
lcsh:Microbiology
Zika virus
Mice
03 medical and health sciences
0302 clinical medicine
Sabethes cyaneus
Aedes
Virology
Animals
Humans
Saliva
Mexico
vector competence
biology
Zika Virus Infection
spillback
Viral Load
biology.organism_classification
United States
3. Good health
Culicidae
030104 developmental biology
Infectious Diseases
sylvatic cycle
Sylvatic cycle
Sylvatic yellow fever
Americas
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Volume :
- 10
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Viruses
- Accession number :
- edsair.doi.dedup.....1579ba71cb1a996abd2df2a86de1228c