Back to Search
Start Over
Stem cell therapy for COVID-19 and other respiratory diseases: Global trends of clinical trials
- Source :
- World J Stem Cells
- Publication Year :
- 2020
-
Abstract
- Respiratory diseases, including coronavirus disease 2019 and chronic obstructive pulmonary disease (COPD), are leading causes of global fatality. There are no effective and curative treatments, but supportive care only. Cell therapy is a promising therapeutic strategy for refractory and unmanageable pulmonary illnesses, as proved by accumulating preclinical studies. Stem cells consist of totipotent, pluripotent, multipotent, and unipotent cells with the potential to differentiate into cell types requested for repair. Mesenchymal stromal cells, endothelial progenitor cells, peripheral blood stem cells, and lung progenitor cells have been applied to clinical trials. To date, the safety and feasibility of stem cell and extracellular vesicles administration have been confirmed by numerous phase I/II trials in patients with COPD, acute respiratory distress syndrome, bronchial dysplasia, idiopathic pulmonary fibrosis, pulmonary artery hypertension, and silicosis. Five routes and a series of doses have been tested for tolerance and advantages of different regimes. In this review, we systematically summarize the global trends for the cell therapy of common airway and lung diseases registered for clinical trials. The future directions for both new clinical trials and preclinical studies are discussed.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Histology
medicine.medical_treatment
Cell therapy
03 medical and health sciences
Idiopathic pulmonary fibrosis
0302 clinical medicine
Internal medicine
Genetics
Medicine
Progenitor cell
Molecular Biology
Genetics (clinical)
COPD
Lung
business.industry
Mesenchymal stem cell
Minireviews
Cell Biology
Stem-cell therapy
medicine.disease
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Stem cell
business
Subjects
Details
- ISSN :
- 19480210
- Volume :
- 12
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- World journal of stem cells
- Accession number :
- edsair.doi.dedup.....1579a413cbaf43972a7cfe3792aa1299