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Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma

Authors :
Xiu-E Xu
Meng-Xiao Zhu
Ling-Ling Sun
Xing-Xing Sun
Zhi-Yong Wu
En-Min Li
Jian-Yi Wu
Jin-Hui Shen
Li-Yan Xu
Qiao Huang
Source :
Acta Histochemica. 115:56-62
Publication Year :
2013
Publisher :
Elsevier BV, 2013.

Abstract

Jumonji AT-rich interactive domain 1B (JARID1B) and PHD finger protein 2 (PHF2), members of the histone demethylases, have been found to be involved in many types of tumors. However, the expression and prognostic significance of JARID1B and PHF2 in esophageal squamous cell carcinoma (ESCC) still remains unclear. In this study, JARID1B and PHF2 expression were detected on tissue microarrays of ESCC samples in 120 cases using immunohistochemical staining. Our results showed that JARID1B and PHF2 were overexpressed in ESCCs. In addition, a significant correlation was observed between JARID1B nuclear expression level and histological grade (P=0.003). Kaplan-Meier survival analysis showed a tendency that high cytoplasmic expression of JARID1B and PHF2 was associated with decreased overall survival of ESCC patients, whereas JARID1B high expression in the nucleus was associated with high overall survival, although there was no statistical significance. Overall, our data suggest that JARID1B and PHF2 are overexpressed in ESCC and that they may play crucial roles in the course of ESCC initiation and/or progression.

Details

ISSN :
00651281
Volume :
115
Database :
OpenAIRE
Journal :
Acta Histochemica
Accession number :
edsair.doi.dedup.....1578d59d4192284ef9842b0b51fbd6e1
Full Text :
https://doi.org/10.1016/j.acthis.2012.04.001