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Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma
- Source :
- Acta Histochemica. 115:56-62
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Jumonji AT-rich interactive domain 1B (JARID1B) and PHD finger protein 2 (PHF2), members of the histone demethylases, have been found to be involved in many types of tumors. However, the expression and prognostic significance of JARID1B and PHF2 in esophageal squamous cell carcinoma (ESCC) still remains unclear. In this study, JARID1B and PHF2 expression were detected on tissue microarrays of ESCC samples in 120 cases using immunohistochemical staining. Our results showed that JARID1B and PHF2 were overexpressed in ESCCs. In addition, a significant correlation was observed between JARID1B nuclear expression level and histological grade (P=0.003). Kaplan-Meier survival analysis showed a tendency that high cytoplasmic expression of JARID1B and PHF2 was associated with decreased overall survival of ESCC patients, whereas JARID1B high expression in the nucleus was associated with high overall survival, although there was no statistical significance. Overall, our data suggest that JARID1B and PHF2 are overexpressed in ESCC and that they may play crucial roles in the course of ESCC initiation and/or progression.
- Subjects :
- Male
Jumonji Domain-Containing Histone Demethylases
Histology
Esophageal Neoplasms
Repressor
Carcinoma
medicine
Humans
Nuclear protein
neoplasms
Survival analysis
Retrospective Studies
Homeodomain Proteins
Tissue microarray
biology
Nuclear Proteins
Cell Biology
General Medicine
Middle Aged
Prognosis
medicine.disease
Survival Analysis
Molecular biology
digestive system diseases
Repressor Proteins
PHD finger
Carcinoma, Squamous Cell
Disease Progression
biology.protein
Immunohistochemistry
Female
JARID1B
Subjects
Details
- ISSN :
- 00651281
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- Acta Histochemica
- Accession number :
- edsair.doi.dedup.....1578d59d4192284ef9842b0b51fbd6e1
- Full Text :
- https://doi.org/10.1016/j.acthis.2012.04.001