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Longitudinal evaluation of thyroid autoimmunity and function in pregnant Korean women
- Source :
- Clinical chemistry and laboratory medicine. 51(12)
- Publication Year :
- 2013
-
Abstract
- Background: Maternal thyroid dysfunction during pregnancy has been associated with adverse outcomes for both the mother and child. For this reason, it is important to understand thyroid status in pregnant women. However, there are relatively few published studies that examine thyroid function tests (TFT) and thyroid autoimmunity in non-Western pregnant women. Methods: Serum samples were longitudinally collected throughout pregnancy from 108 Korean women. TFT, thyroid peroxidase antibodies (TPO-Ab), and thyroglobulin antibodies (Tg-Ab) testing was performed. The impact of gestational age on TPO-Ab and Tg-Ab levels was evaluated and gestational age-specific reference intervals for TFT were established in antibody negative women. Results: In the first trimester, TPO-Ab and Tg-Ab were positive in 13.9% and 16.7% of women, respectively. For antibody positive women, median autoantibody levels for TPO-Ab and Tg-Ab dropped from first trimester to near term (133.7–10.5 IU/mL, and 162.1–21.9 IU/mL, respectively). Antibody status influenced thyroid stimulating hormone (TSH) during the first trimester, and TSH, free T4 (FT4) and total T4 (TT4) in the early second trimester. Later in gestation, no significant differences in TFT were found based on antibody status. Gestational age-specific reference intervals for TFT were calculated in antibody negative women. Conclusions: Laboratory evidence of autoimmune thyroid disease (AITD) is common in this population of pregnant Korean women. Antibody status influences TFT values in the first and early second trimester. Thyroid autoantibody status and titer change in an individual-specific manner throughout pregnancy. Gestational age-specific reference intervals should be utilized for interpretation of TFT results in pregnant women.
- Subjects :
- Adult
endocrine system
medicine.medical_specialty
medicine.medical_treatment
Clinical Biochemistry
Thyroid Gland
Autoimmunity
Thyroid Function Tests
Thyroid function tests
Iodide Peroxidase
Thyroglobulin
Autoimmune Diseases
Thyroid peroxidase
Pregnancy
Internal medicine
Republic of Korea
Medicine
Humans
Longitudinal Studies
Autoantibodies
biology
medicine.diagnostic_test
business.industry
Obstetrics
Biochemistry (medical)
Thyroid
Gestational age
General Medicine
medicine.disease
Thyroid Diseases
Anti-thyroid autoantibodies
Pregnancy Complications
medicine.anatomical_structure
Endocrinology
biology.protein
Female
Thyroid function
business
Subjects
Details
- ISSN :
- 14374331
- Volume :
- 51
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Clinical chemistry and laboratory medicine
- Accession number :
- edsair.doi.dedup.....157694fc53fa15dff218dc9c08c3c8c5