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Archaeal virus with exceptional virion architecture and the largest single-stranded DNA genome
- Source :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (33), pp.13386-91. ⟨10.1073/pnas.1203668109⟩, Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (33), pp.13386-91. ⟨10.1073/pnas.1203668109⟩
- Publication Year :
- 2012
- Publisher :
- HAL CCSD, 2012.
-
Abstract
- Known viruses build their particles using a restricted number of redundant structural solutions. Here, we describe the Aeropyrum coil-shaped virus (ACV), of the hyperthermophilic archaeon Aeropyrum pernix , with a virion architecture not previously observed in the viral world. The nonenveloped, hollow, cylindrical virion is formed from a coiling fiber, which consists of two intertwining halves of a single circular nucleoprotein. The virus ACV is also exceptional for its genomic properties. It is the only virus with a single-stranded (ss) DNA genome among the known hyperthermophilic archaeal viruses. Moreover, the size of its circular genome, 24,893 nt, is double that of the largest known ssDNA genome, suggesting an efficient solution for keeping ssDNA intact at 90–95 °C, the optimal temperature range of A. pernix growth. The genome content of ACV is in line with its unique morphology and confirms that ACV is not closely related to any known virus.
- Subjects :
- Archaeal Viruses
Aeropyrum
viruses
Molecular Sequence Data
DNA, Single-Stranded
Genome, Viral
Biology
Genome
Models, Biological
Virus
03 medical and health sciences
chemistry.chemical_compound
Aeropyrum pernix
Base sequence
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
030304 developmental biology
Genetics
Electrophoresis, Agar Gel
0303 health sciences
Multidisciplinary
Base Sequence
030306 microbiology
DNA Viruses
Virion
Biological Sciences
biology.organism_classification
Virology
Nucleoprotein
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
chemistry
DNA, Circular
DNA
Subjects
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (33), pp.13386-91. ⟨10.1073/pnas.1203668109⟩, Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (33), pp.13386-91. ⟨10.1073/pnas.1203668109⟩
- Accession number :
- edsair.doi.dedup.....1576372dcd4bb778b61cb050a24a4495