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Decreased mean platelet volume is associated with microsatellite instability in colorectal cancer: A propensity score-matched analysis
- Source :
- Cancer Biomarkers. 31:351-359
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- BACKGROUND: Patients with microsatellite instability-high (MSI-H) colorectal cancer (CRC) generally have a better prognosis and a more effective immune response than patients with microsatellite stable (MSS) CRC. Moreover, activated platelets play a crucial role in modulating innate immune cells. Mean platelet volume (MPV) is an indicator of platelet activation. This study is to examine the association between MPV and MSI status in CRC. METHODS: We collected the clinical and pathological variables of 424 CRC patients diagnosed at the Harbin Medical University Cancer Hospital from January 2018 to December 2018. Associations between MPV levels and MSI status were examined. Propensity score matching (PSM) was performed to reduce the possibility of selection bias. RESULTS: 424 CRC patients were divided into low-MPV group and high-MPV group according to the optimal cut-off value of MPV. 131 high-MPV patients were matched to low-MPV counterparts in a 1:1 ratio by propensity score matching. As MPV levels increased, the percentage of patients with MSI-H reduced. Furthermore, compared with MSS group, the MSI-H group had a significantly lower MPV levels (p= 0.003 after matching). In addition, logistic regression analysis identified reduced MPV as an independent risk factor for MSI-H in CRC patients after controlling for other potential parameters. CONCLUSION: Lower MPV is associated with MSI-H subtype of CRC. Further study on MPV in MSI-H CRC is warranted.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
Colorectal cancer
03 medical and health sciences
0302 clinical medicine
Decreased mean platelet volume
Internal medicine
Genetics
Humans
Medicine
Platelet activation
Risk factor
Mean platelet volume
Propensity Score
neoplasms
Aged
030304 developmental biology
0303 health sciences
business.industry
Cancer
Microsatellite instability
General Medicine
medicine.disease
digestive system diseases
030220 oncology & carcinogenesis
Propensity score matching
Female
Microsatellite Instability
Colorectal Neoplasms
business
Mean Platelet Volume
Subjects
Details
- ISSN :
- 18758592 and 15740153
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Cancer Biomarkers
- Accession number :
- edsair.doi.dedup.....1574eea5a984a223b4dc329908e5d787
- Full Text :
- https://doi.org/10.3233/cbm-203250