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Decreased mean platelet volume is associated with microsatellite instability in colorectal cancer: A propensity score-matched analysis

Authors :
Zengyao Liu
Beibei Zhang
Shuang Fu
Rui-tao Wang
Guangyu Wang
Wen Wang
Source :
Cancer Biomarkers. 31:351-359
Publication Year :
2021
Publisher :
IOS Press, 2021.

Abstract

BACKGROUND: Patients with microsatellite instability-high (MSI-H) colorectal cancer (CRC) generally have a better prognosis and a more effective immune response than patients with microsatellite stable (MSS) CRC. Moreover, activated platelets play a crucial role in modulating innate immune cells. Mean platelet volume (MPV) is an indicator of platelet activation. This study is to examine the association between MPV and MSI status in CRC. METHODS: We collected the clinical and pathological variables of 424 CRC patients diagnosed at the Harbin Medical University Cancer Hospital from January 2018 to December 2018. Associations between MPV levels and MSI status were examined. Propensity score matching (PSM) was performed to reduce the possibility of selection bias. RESULTS: 424 CRC patients were divided into low-MPV group and high-MPV group according to the optimal cut-off value of MPV. 131 high-MPV patients were matched to low-MPV counterparts in a 1:1 ratio by propensity score matching. As MPV levels increased, the percentage of patients with MSI-H reduced. Furthermore, compared with MSS group, the MSI-H group had a significantly lower MPV levels (p= 0.003 after matching). In addition, logistic regression analysis identified reduced MPV as an independent risk factor for MSI-H in CRC patients after controlling for other potential parameters. CONCLUSION: Lower MPV is associated with MSI-H subtype of CRC. Further study on MPV in MSI-H CRC is warranted.

Details

ISSN :
18758592 and 15740153
Volume :
31
Database :
OpenAIRE
Journal :
Cancer Biomarkers
Accession number :
edsair.doi.dedup.....1574eea5a984a223b4dc329908e5d787
Full Text :
https://doi.org/10.3233/cbm-203250