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Assessment of combined 24,25(oh)2d3 and 1α(oh)d3 therapy for bone disease in dialysis patients
- Source :
- Bone. 13:369-377
- Publication Year :
- 1992
- Publisher :
- Elsevier BV, 1992.
-
Abstract
- An increasing body of experimental data suggests a role for 24,25(OH)2D3 in bone metabolism. The present study was carried out to assess a possible therapeutic role of this vitamin D metabolite in renal osteodystrophy. Twenty-two chronic dialysis patients, most of whom were previously maintained on 1 alpha (OH)D3 therapy, received additional treatment with 10 micrograms/day 24,25(OH)2D3 and were compared to 19 patients receiving 1 alpha (OH)D3 alone. Analysis of transiliac bone biopsies obtained at study entry and following 10-16 months of treatment revealed that the combined therapy produced a decrease in bone turnover. Specifically, the addition of 24,25(OH)2D3 inhibited an increase in trabecular bone volume (BV/TV) and suppressed osteoclastic parameters. Thus BV/TV increased from 26.2 +/- 8.6 to 32.1 +/- 7.5% (p0.01) in the 1 alpha (OH)D3 group, but it remained unchanged in the combined therapy group. In contrast, the eroded surface (ES/BS), the osteoclast surface (Oc.S/BS), and the osteoclast numbers were significantly suppressed in patients receiving both 24,25(OH)2D3 and 1 alpha (OH)D3, as compared with those receiving 1 alpha (OH)D3 alone (p0.01, p0.01, and p0.001, respectively). These improvements were independent of changes in 1 alpha (OH)D3 dosage. The extent of bone aluminium deposits was unrelated to the administration of 24,25(OH)2D3 or to its effect. 24,25(OH)2D3 therapy was not associated with any adverse effects.
- Subjects :
- Adult
Male
medicine.medical_specialty
Histology
24,25-Dihydroxyvitamin D 3
Bone disease
Physiology
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Phosphates
Bone remodeling
Bone Density
Renal Dialysis
Osteoclast
Internal medicine
medicine
Vitamin D and neurology
Humans
Renal osteodystrophy
Dialysis
Aged
Chronic Kidney Disease-Mineral and Bone Disorder
Chemotherapy
Hydroxycholecalciferols
business.industry
Middle Aged
Alkaline Phosphatase
medicine.disease
medicine.anatomical_structure
Endocrinology
Creatinine
Calcium
Drug Therapy, Combination
Female
Hemodialysis
business
Subjects
Details
- ISSN :
- 87563282
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Bone
- Accession number :
- edsair.doi.dedup.....15727fa2222ab4f26af9fde39795ed4b