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ADIPOQ Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: The GOLDN Study
- Source :
- Obesity. 17:510-517
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Serum adiponectin levels have been positively associated with insulin sensitivity and are decreased in type 2 diabetes (T2D) and obesity. Genetic and environmental factors influence serum adiponectin and may contribute to risk of metabolic syndrome and T2D. Therefore, we investigated the effect of ADIPOQ single-nucleotide polymorphisms (SNPs), -11377CG and -11391GA, on metabolic-related traits, and their modulation by dietary fat in white Americans. Data were collected from 1,083 subjects participating in the Genetics of Lipid Lowering Drugs and Diet Network study. Mean serum adiponectin concentration was higher for carriers of the -11391A allele (P = 0.001) but lower for the -11377G allele carriers (P = 0.017). Moreover, we found a significant association with obesity traits for the -11391GA SNP. Carriers of the -11391A allele had significantly lower weight (P = 0.029), BMI (P = 0.019), waist (P = 0.003), and hip circumferences (P = 0.004) compared to noncarriers. Interestingly, the associations of the -11391GA with BMI and obesity risk were modified by monounsaturated fatty acids (MUFAs) intake (P-interaction = 0.021 and 0.034 for BMI and obesity risk, respectively). In subjects with MUFA intake above the median (or =13% of energy intake), -11391A carriers had lower BMI (27.1 kg/m(2) for GA+AA vs. 29.1 kg/m(2) for GG, P = 0.002) and decreased obesity risk (odds ratio for -11391A = 0.52, 95% confidence interval (CI); 0.28-0.96; P = 0.031). However, we did not detect genotype-related differences for BMI or obesity in subjects with MUFA intake13%. Our findings support a significant association between the -11391GA SNPs and obesity-related traits and the potential to moderate such effects using dietary modification.
- Subjects :
- Adult
Male
medicine.medical_specialty
Waist
Adolescent
Genotype
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Single-nucleotide polymorphism
Type 2 diabetes
Polymorphism, Single Nucleotide
Article
Body Mass Index
Fatty Acids, Monounsaturated
Young Adult
Endocrinology
Dietary Fats, Unsaturated
Risk Factors
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
Obesity
Alleles
Aged
Aged, 80 and over
Nutrition and Dietetics
Adiponectin
business.industry
Odds ratio
Middle Aged
medicine.disease
Health Surveys
Female
Metabolic syndrome
business
Body mass index
Subjects
Details
- ISSN :
- 19307381
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Obesity
- Accession number :
- edsair.doi.dedup.....1570b063214c2f350472f8ec420d088e
- Full Text :
- https://doi.org/10.1038/oby.2008.583