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Studies on new dehydropeptidase inhibitors. III. Biological properties of WS1358A1
- Source :
- The Journal of antibiotics. 43(3)
- Publication Year :
- 1990
-
Abstract
- WS1358A1, a novel inhibitor of renal dehydropeptidase (DHP), augmented the urinary recovery of a carbapenem antibiotic imipenem and improved its protective effect in experimental infections when simultaneously administered to mice with the antibiotic. WS1358A1 was a competitive DHP inhibitor with a Ki value of 1.6 x 10(-7) M.
- Subjects :
- endocrine system
Carbapenem
Imipenem
Dipeptidases
medicine.drug_class
Swine
Antibiotics
Pharmacology
Kidney
Glutarates
Mice
Pharmacokinetics
Drug Discovery
medicine
Animals
Mice, Inbred ICR
biology
Biological activity
Drug interaction
Staphylococcal Infections
Kinetics
medicine.anatomical_structure
Biochemistry
Enzyme inhibitor
biology.protein
Drug Therapy, Combination
Female
medicine.drug
Subjects
Details
- ISSN :
- 00218820
- Volume :
- 43
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Journal of antibiotics
- Accession number :
- edsair.doi.dedup.....156bb75f73af0e4323e50559c0e602f4