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Circulating Levels of VEGF and CXCL1 Are Predictive of Metastatic Organotropismin in Patients with Colorectal Cancer
- Source :
- Anticancer research. 37(9)
- Publication Year :
- 2017
-
Abstract
- Colorectal cancer is the most common cancer of the gastrointestinal system and has a marked preference to metastasize to distant organs. In this study, we investigated whether levels of circulating serum pro-angiogenic cytokine such as chemokine (C-X-C motif) ligand 1 (melanoma growth-stimulating activity, alpha; CXCL1) and vascular endothelial growth factor (VEGF) have a role in favoring the colonization of metastatic cells at preferential sites and determined their prognostic significance in a cohort of 103 patients with metastatic colorectal cancer. Importantly, we found that the presence of elevated circulating levels of VEGF and CXCL1 are predictive of liver and lung metastasis, respectively. Moreover, the presence of a high serum VEGF level represents a negative prognostic factor for patients with liver metastases, with a worse prognosis than patients with lung metastasis. This suggests an additional role for circulating cytokines as a predictive tool for cancer prognosis and diagnosis, as well as for assessment of tumor sensitivity to anticancer therapy.
- Subjects :
- 0301 basic medicine
Adult
Male
Vascular Endothelial Growth Factor A
Cancer Research
Chemokine
Lung Neoplasms
Colorectal cancer
Angiogenesis
medicine.medical_treatment
Chemokine CXCL1
Metastasis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Humans
Neoplasm Metastasis
Aged
Aged, 80 and over
biology
business.industry
Melanoma
Liver Neoplasms
General Medicine
Middle Aged
medicine.disease
Prognosis
Survival Analysis
CXCL1
Vascular endothelial growth factor
030104 developmental biology
Cytokine
Oncology
chemistry
030220 oncology & carcinogenesis
Cancer research
biology.protein
Female
business
Colorectal Neoplasms
Subjects
Details
- ISSN :
- 17917530
- Volume :
- 37
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Anticancer research
- Accession number :
- edsair.doi.dedup.....156642a1c197edcc3400c46c217bb720