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β1 Syntrophin Supports Autophagy Initiation and Protects against Cerulein-Induced Acute Pancreatitis
- Source :
- The American journal of pathology. 189(4)
- Publication Year :
- 2018
-
Abstract
- Syntrophins are a family of proteins forming membrane-anchored scaffolds and serving as adaptors for various transmembrane and intracellular signaling molecules. To understand the physiological roles of β1 syntrophin, one of the least characterized members, we generated mouse models to eliminate β1 syntrophin specifically in the endocrine or exocrine pancreas. β1 syntrophin is dispensable for the morphology and function of insulin-producing β cells. However, mice with β1 syntrophin deletion in exocrine acinar cells exhibit increased severity of cerulein-induced acute pancreatitis. Reduced expression of cystic fibrosis transmembrane conductance regulator and dilation of acinar lumen are potential predisposition factors. During the disease progression, a relative lack of autophagy is associated with deficiencies in both actin assembly and endoplasmic reticulum nucleation. Our findings reveal, for the first time, that β1 syntrophin is a critical regulator of actin cytoskeleton and autophagy in pancreatic acinar cells and is potently protective against cerulein-induced acute pancreatitis.
- Subjects :
- 0301 basic medicine
Cell signaling
Cystic Fibrosis Transmembrane Conductance Regulator
Acinar Cells
Protective Agents
Article
Pathology and Forensic Medicine
03 medical and health sciences
Mice
Autophagy
Animals
Pancreas
Actin
Syntrophin
Mice, Knockout
030102 biochemistry & molecular biology
biology
Chemistry
Endoplasmic reticulum
Actin cytoskeleton
Cystic fibrosis transmembrane conductance regulator
Transmembrane protein
Cell biology
Mice, Inbred C57BL
030104 developmental biology
Pancreatitis
Dystrophin-Associated Proteins
biology.protein
Ceruletide
Subjects
Details
- ISSN :
- 15252191
- Volume :
- 189
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The American journal of pathology
- Accession number :
- edsair.doi.dedup.....155d2b2ae6d21c255fffb3dbec6d67b0