Back to Search
Start Over
beta-Endorphin and beta-lipotropin plasma levels in chronic schizophrenia, primary affective disorders and secondary affective disorders
- Publication Year :
- 1981
-
Abstract
- Plasma levels of β-endorphin (β-EP), β-lipotropin (β-LPH) and ACTH were assayed in 15 chronic schizophrenics, nine patients with primary affective disorders (PAD) and seven patients with secondary affective disorders (SAD). Patients received no therapy for 10 days prior to study. All subjects were studied once; eight schizophrenics were studied again after 10 days of Haloperidol therapy, at a dose of 0.1 mg/kg body weight. β-LPH levels were significantly higher in the schizophrenics without hallucinations and in the PAD and SAD patients in comparison to the controls; β-EP levels were higher in the schizophrenics and SAD patients compared to the controls; and ACTH concentrations were significantly lower in the SAD than in the PAD patients. Haloperidol therapy failed to induce significant changes in β-LPH, β-EP or ACTH plasma levels. Statistical evaluation by multiple linear regression confirmed the significant positive correlations among β-LPH, β-EP and ACTH in the controls, schizophrenics with hallucinations, and PAD and SAD patients, while inverse correlations between β-LPH and the other two peptides were found in the schizophrenics without hallucinations. The same analysis revealed that, while in the PAD patients equimolar amounts of the three peptides occurred, the SAD patients were characterized by ACTH/β-LPH and ACTH/β-EP molar ratios of 0.5. Although these results are preliminary, they seem to indicate that β-LPH, β-EP and ACTH secretion patterns in chronic schizophrenia, PAD and SAD may help in revealing specific groups of patients with different biochemical substrates.
- Subjects :
- Male
Endocrinology, Diabetes and Metabolism
Lipotropin
β-lipotropin
ACTH secretion
chemistry.chemical_compound
Endocrinology
Haloperidol
chronic schizophrenia
beta-Endorphin
Plasma opioids
Middle Aged
Psychiatry and Mental health
Chronic schizophrenia
Female
Biological psychiatry
Psychology
ACTH
primary affective disorders
secondary affective disorders
β-endorphin
hormones, hormone substitutes, and hormone antagonists
medicine.drug
medicine.hormone
Adrenocorticotropic Hormone
blood, Adult, Chronic Disease, Endorphins
blood, Female, Haloperidol
therapeutic use, Humans, Male, Middle Aged, Mood Disorders
blood/drug therapy, Schizophrenia
blood/drug therapy, beta-Endorphin, beta-Lipotropin
blood
Adult
beta-Lipotropin
endocrine system
medicine.medical_specialty
Body weight
behavioral disciplines and activities
Internal medicine
medicine
Humans
Biological Psychiatry
Endocrine and Autonomic Systems
Mood Disorders
Plasma levels
chemistry
therapeutic use
Chronic Disease
Schizophrenia
Endorphins
blood/drug therapy
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....154506adcc972898a1925644f77be20a