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Fluorocarbon Plasma Gas Passivation Enhances Performance of Porous Silicon for Desorption/Ionization Mass Spectrometry
- Source :
- ACS sensors. 5(10)
- Publication Year :
- 2020
-
Abstract
- Desorption/ionization on porous silicon mass spectrometry (DIOS-MS) is shown to be a powerful technique for the sensing of low-molecular-weight compounds, including drugs and their metabolites. Surface modification of DIOS surfaces is required to increase analytical performance and ensure stability. However, common wet chemical modification techniques use fluorosilanes, which are less suitable for high-throughput manufacturing and analytical repeatability. Here, we report an alternative, rapid functionalization technique for DIOS surfaces using plasma polymerization (ppDIOS). We demonstrate the detection of drugs, metabolites, pesticides, and doping agents, directly from biological matrices, with molecular confirmation performed using the fragmentation capabilities of a tandem MS instrument. Furthermore, the ppDIOS surfaces were found to be stable over a 162 day period with no loss of reproducibility and sensitivity. This alternative functionalization technique is cost-effective and amenable to upscaling, ensuring avenues for the high-throughput manufacture and detection of hundreds of analytes across various applications while still maintaining the gold-standard clinical technique using mass spectrometry.
- Subjects :
- Silicon
Materials science
Passivation
Inorganic chemistry
Bioengineering
02 engineering and technology
Porous silicon
Mass spectrometry
01 natural sciences
Drug detection
Ionization
Desorption
Fluorocarbon
Instrumentation
Fluid Flow and Transfer Processes
Fluorocarbons
Process Chemistry and Technology
010401 analytical chemistry
technology, industry, and agriculture
Reproducibility of Results
Plasma
equipment and supplies
021001 nanoscience & nanotechnology
0104 chemical sciences
3. Good health
Pharmaceutical Preparations
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
0210 nano-technology
Porosity
Subjects
Details
- ISSN :
- 23793694
- Volume :
- 5
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- ACS sensors
- Accession number :
- edsair.doi.dedup.....154003d74155f201f657faea2e046c2e