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Ocular Inflammatory Disorders in Autoimmune Lymphoproliferative Syndrome (ALPS)
- Source :
- Ocular immunology and inflammation. 25(5)
- Publication Year :
- 2016
-
Abstract
- Purpose: To describe inflammatory ocular findings in patients with autoimmune lymphoproliferative syndrome (ALPS).Methods: A retrospective review of medical records for ALPS patients seen at the National Eye Institute between 2003 and 2013.Results: A total of 29 ALPS patients previously referred for ocular or visual symptoms or with a history of prolonged corticosteroid use, were identified. Mean age was 20 years (range: 4–66 years). The majority were male (n = 21, 72.4%) and Caucasian (n = 24, 82.8%). Ten (34.5%) had abnormal ocular findings, the most common of which was an ocular inflammatory disorder (n = 4, 13.8%). Uveitis was seen in two patients with ALPS-FAS and one with ALPS-U, all of whom required long-term systemic immunosuppression. One patient with ALPS-FAS had a history of optic neuritis.Conclusions: ALPS can have intraocular inflammatory manifestations that require routine follow-up to ensure appropriate and timely treatment of intraocular disease. Long-term immunosuppression may be ...
- Subjects :
- musculoskeletal diseases
0301 basic medicine
Adult
Male
medicine.medical_specialty
Visual acuity
Optic Neuritis
genetic structures
Adolescent
medicine.medical_treatment
Visual Acuity
Disease
Article
Uveitis
03 medical and health sciences
Young Adult
stomatognathic system
medicine
Immunology and Allergy
Humans
Optic neuritis
Young adult
Child
Aged
Retrospective Studies
Inflammation
business.industry
Autoimmune Lymphoproliferative Syndrome
Immunosuppression
Retrospective cohort study
Middle Aged
medicine.disease
Dermatology
eye diseases
Ophthalmology
030104 developmental biology
Autoimmune lymphoproliferative syndrome
Child, Preschool
Immunology
Female
sense organs
medicine.symptom
business
Subjects
Details
- ISSN :
- 17445078
- Volume :
- 25
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Ocular immunology and inflammation
- Accession number :
- edsair.doi.dedup.....153b887c56382590fae2683d202a23fd