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Pattern and Rate of Cognitive Decline in Cerebral Small Vessel Disease: A Prospective Study
- Source :
- PLoS ONE, Vol 10, Iss 8, p e0135523 (2015), Lawrence, A J, Brookes, R L, Zeestraten, E A, Barrick, T R, Morris, R G & Markus, H S 2015, ' Pattern and rate of cognitive decline in cerebral small vessel disease : a prospective study ', PLoS ONE, vol. 10, no. 8, e0135523, pp. 1-15 . https://doi.org/10.1371/journal.pone.0135523, PLoS ONE
- Publication Year :
- 2015
- Publisher :
- Public Library of Science (PLoS), 2015.
-
Abstract
- OBJECTIVES: Cognitive impairment, predominantly affecting processing speed and executive function, is an important consequence of cerebral small vessel disease (SVD). To date, few longitudinal studies of cognition in SVD have been conducted. We determined the pattern and rate of cognitive decline in SVD and used the results to determine sample size calculations for clinical trials of interventions reducing cognitive decline.METHODS: 121 patients with MRI confirmed lacunar stroke and leukoaraiosis were enrolled into the prospective St George's Cognition And Neuroimaging in Stroke (SCANS) study. Patients attended one baseline and three annual cognitive assessments providing 36 month follow-up data. Neuropsychological assessment comprised a battery of tests assessing working memory, long-term (episodic) memory, processing speed and executive function. We calculated annualized change in cognition for the 98 patients who completed at least two time-points.RESULTS: Task performance was heterogeneous, but significant cognitive decline was found for the executive function index (pCONCLUSIONS: The pattern of cognitive decline seen in SVD over three years is consistent with the pattern of impairments at baseline. Rates of decline were slow and sample sizes would need to be large for clinical trials aimed at halting decline beyond initial diagnosis using cognitive scores as an outcome measure. This emphasizes the importance of more sensitive surrogate markers in this disease.
- Subjects :
- Male
medicine.medical_specialty
Lacunar stroke
Science
Neuropsychological Tests
Physical medicine and rehabilitation
Cognition
medicine
Humans
Neuropsychological assessment
Longitudinal Studies
Prospective Studies
Cognitive decline
Stroke
Aged
Multidisciplinary
medicine.diagnostic_test
Working memory
business.industry
Leukoaraiosis
Middle Aged
medicine.disease
3. Good health
Memory, Short-Term
Sample size determination
Cerebral Small Vessel Diseases
Medicine
Female
business
Cognition Disorders
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 10
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....1530005ab8aae6059d2b62d5c9b5cd96