Supplementary Figure Legends, Table Legends, Figures S1 - S4 from DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia

Supplementary Figure S1. Dnmt3a haploinsufficiency transforms Flt3ITD MPN into an AML with clonogenic c-Kit+ leukemic stem and progenitors in the spleen. Supplementary Figure S2. Comparative patterns of differential global DNA methylation in DNMT3A-mutant human and murine AML. Supplementary Figure S3. Hematopoietic stem cells/progenitor and c-Myc signatures are upregulated in murine AML. Supplementary Figure S4. DNMT3A rescued murine Flt3ITD/ITD;Dnmt3afl/fl MxCre AML hypermethylated regions correspond to HSPC-like populations.