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Follistatin-Like Protein-1 Is a Novel Proinflammatory Molecule
- Source :
- Scopus-Elsevier
- Publication Year :
- 2006
- Publisher :
- The American Association of Immunologists, 2006.
-
Abstract
- While analyzing gene expression in collagen-induced arthritis, we discovered that a poorly characterized gene, follistatin-like protein 1 (FSTL-1), is highly overexpressed in mouse paws during early arthritis, especially at the interface of synovial pannus and eroding bone. In this study, we show that FSTL-1 is a novel proinflammatory molecule with a previously unrecognized role in inflammation. Transfection of FSTL-1 into macrophages and fibroblasts leads to up-regulation of proinflammatory cytokines, including IL-1β, TNF-α, and IL-6. Overexpression of FSTL-1 in mouse paws by gene transfer results in severe paw swelling and arthritis.
- Subjects :
- Follistatin-Related Proteins
Immunology
Arthritis
Pannus
Enzyme-Linked Immunosorbent Assay
Inflammation
Transfection
Proinflammatory cytokine
Mice
Chlorocebus aethiops
Gene expression
medicine
Animals
Humans
Immunology and Allergy
biology
Reverse Transcriptase Polymerase Chain Reaction
Chemistry
Macrophages
Fibroblasts
medicine.disease
Arthritis, Experimental
Immunohistochemistry
Cell biology
COS Cells
biology.protein
Cytokines
medicine.symptom
Follistatin
Subjects
Details
- ISSN :
- 15506606 and 00221767
- Volume :
- 177
- Database :
- OpenAIRE
- Journal :
- The Journal of Immunology
- Accession number :
- edsair.doi.dedup.....152d82fee249bece7e17ac7e060489f3