The Kinetics of Reaction between Phenacyl Bromide and Aniline in Methyl and Iso-Amyl Alcohols

The reaction of phenacyl bromide with aniline and in derivatives is a bimolecular nucleophilic sub­stitution reaction. The values a Arrhenius parameters in the equation k=Ae -E/RThave been calculated for the reaction, which are found to be more or Less constant throughout the series. The effect of the sub­stituents in benzene nucleus of aniline has also been calculated and the additivity rule has been found to hold good for the series. The plots of specific rate constants of different reactions against the dipole moments of substituted anilines have been shown to be linear. The Hammetts equation also applies well to the reaction series. The change of solvent from methyl to iso-amyl alcohol does not change the frequency factor; but a slight change is only observed in energy of activation.