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Computed Tomography Radiomics Predicts HPV Status and Local Tumor Control After Definitive Radiochemotherapy in Head and Neck Squamous Cell Carcinoma
- Source :
- International journal of radiation oncology, biology, physics. 99(4)
- Publication Year :
- 2016
-
Abstract
- Purpose This study aimed to predict local tumor control (LC) after radiochemotherapy of head and neck squamous cell carcinoma (HNSCC) and human papillomavirus (HPV) status using computed tomography (CT) radiomics. Methods and Materials HNSCC patients treated with definitive radiochemotherapy were included in the retrospective study approved by the local ethical commission (93 and 56 patients in the training and validation cohorts, respectively). Three hundred seventeen CT radiomic features, including those based on shape, intensity, texture, and wavelet transform, were calculated in the primary tumor region. Cox and logistic regression models were built to predict LC and HPV status, respectively. The best-performing features in the univariable analysis were included in the multivariable analysis after the exclusion of redundant features. The quality of the models was assessed using the concordance index (CI) for modeling of LC and receiver operating characteristics area under the curve (AUC) for HPV status prediction. The radiomics LC model was compared to a model incorporating clinical parameters (tumor stage, volume, and HPV status) and a mixed model. Results A radiomic signature comprising 3 features was significantly associated with LC (CI training = 0.75 and CI validation = 0.78), showing that tumors with a more heterogeneous CT density distribution are at risk for decreased LC. The addition of clinical parameters to the radiomics model slightly improved the model in the training cohort but not in the validation cohort. Another radiomic signature showed good performance in HPV status prediction (AUC training = 0.85 and AUC validation = 0.78) and indicated that HPV-positive tumors have a more homogenous CT density distribution. Conclusions Heterogeneity of HNSCC tumor density, quantified by CT radiomics, is associated with LC after radiochemotherapy and HPV status.
- Subjects :
- Oncology
Male
Cancer Research
Pathology
Cetuximab
Contrast Media
030218 nuclear medicine & medical imaging
0302 clinical medicine
Antineoplastic Combined Chemotherapy Protocols
1306 Cancer Research
Papillomaviridae
Radiation
biology
Chemoradiotherapy
Middle Aged
Primary tumor
10044 Clinic for Radiation Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Area Under Curve
Carcinoma, Squamous Cell
2730 Oncology
Female
Adult
medicine.medical_specialty
610 Medicine & health
03 medical and health sciences
Internal medicine
10049 Institute of Pathology and Molecular Pathology
Carcinoma
medicine
2741 Radiology, Nuclear Medicine and Imaging
Humans
Radiology, Nuclear Medicine and imaging
Aged
Proportional Hazards Models
Retrospective Studies
Analysis of Variance
Receiver operating characteristic
Proportional hazards model
business.industry
Squamous Cell Carcinoma of Head and Neck
Papillomavirus Infections
Retrospective cohort study
biology.organism_classification
medicine.disease
Head and neck squamous-cell carcinoma
3108 Radiation
Logistic Models
Cisplatin
business
Tomography, X-Ray Computed
Subjects
Details
- ISSN :
- 1879355X
- Volume :
- 99
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- International journal of radiation oncology, biology, physics
- Accession number :
- edsair.doi.dedup.....15256ab6a58d12c46c70522f8980acc8