Back to Search
Start Over
Opportunistic CNS infection after bone marrow transplantation
- Source :
- Bone Marrow Transplantation. 23:1167-1176
- Publication Year :
- 1999
- Publisher :
- Springer Science and Business Media LLC, 1999.
-
Abstract
- We retrospectively identified opportunistic CNS infections in 655 patients who had undergone allogeneic, syngeneic or autologous BMT or PBSCT between 1990 and 1997. Twenty-seven patients (4%) developed CNS infections. All CNS infections occurred in allogeneic BMT or PBSCT patients. The most common CNS infections were toxoplasma encephalitis (74%) and cerebral aspergillosis (18%). Furthermore, we identified one patient with candida encephalitis and one patient with viral encephalitis. Overall mortality of patients with opportunistic CNS infection was 67%. There were two different groups of toxoplasma encephalitis with a different appearance on MR imaging. The first group showed edema, but no gadolinium enhancement, whereas the second group exhibited typical MRI appearances with the exception of frequent hemorrhagic transformation. The first group had a significant shorter latency between BMT and onset of CNS infection (mean 45 days vs 180 days, P = 0.02), a significant higher daily dose of corticosteroids as treatment for graft-versus-host disease (GVHD) (P = 0.01), more severe GVHD and a higher mortality (71% vs 36%). This study shows that the most common CNS infections in our patient population are toxoplasma encephalitis and cerebral aspergillosis, that there are two distinct subgroups of toxoplasma encephalitis and that CNS infections occur after allogeneic BMT only.
- Subjects :
- Adult
Male
Adolescent
Opportunistic infection
Opportunistic Infections
Aspergillosis
medicine
Humans
Transplantation, Homologous
Encephalitis, Viral
Mycosis
Bone Marrow Transplantation
Retrospective Studies
Brain Diseases
Transplantation
business.industry
Viral encephalitis
Candidiasis
Hematology
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Toxoplasmosis
medicine.anatomical_structure
Toxoplasmosis, Cerebral
Immunology
Female
Bone marrow
business
Complication
Encephalitis
Subjects
Details
- ISSN :
- 14765365 and 02683369
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Bone Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....151ed8683f878fcccbaf9bee6a0c70ab