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Positron emission tomography with 11C-methionine in primary brain tumor diagnosis
- Source :
- Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 120:51
- Publication Year :
- 2020
- Publisher :
- Media Sphere Publishing Group, 2020.
-
Abstract
- OBJECTIVE To investigate the variations in 11C-methionine uptake in the intact brain tissue and in glial brain tumors of different types. MATERIAL AND METHODS Forty patients (21 men, 19 women) with gliomas, Grade I-IV, underwent 11C-methionine PET-CT and contrast-enhanced MRI. Standardized uptake value (SUV), tumor-to-normal (T/N) ratios and tumor volume were analyzed. RESULTS The high inter-subject variability was detected in the intact brain tissue (SUV in the frontal lobe (FL) varies from 0.47 to 1.73). Amino acid metabolism was more active in women than in men (FL SUV 1.32±0.22 and 1.05±0.24, respectively). T/N ratio better differentiates gliomas by the degree of anaplasia compared to SUV. Gliomas of Grade III (T/N=2.64±0.98) were significantly different (p
- Subjects :
- Male
Pathology
medicine.medical_specialty
Brain tumor
Standardized uptake value
Malignancy
chemistry.chemical_compound
Methionine
Positron Emission Tomography Computed Tomography
medicine
Humans
Carbon Radioisotopes
Anaplasia
medicine.diagnostic_test
Brain Neoplasms
business.industry
medicine.disease
Psychiatry and Mental health
chemistry
Frontal lobe
Positron emission tomography
Positron-Emission Tomography
Female
Neurology (clinical)
medicine.symptom
business
Anaplastic astrocytoma
Subjects
Details
- ISSN :
- 19977298
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova
- Accession number :
- edsair.doi.dedup.....151d7a9f8a3ab27f50fcfbd6ed3660e6