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Genetic association of the neuropilin-1 gene with type 1 diabetes in children: Neuropilin-1 expression in pancreatic islets
- Source :
- Diabetes Research and Clinical Practice. 87:e29-e32
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Minor alleles of two SNPs in intron 9 of the NRP1 gene, which encodes neuropilin-1, were found to be associated with type 1 diabetes (T1D) in children. Neuropilin-1 peptides were confined to islets in human pancreas. This suggests neuropilins-1 could influence the development of some cases of T1D in children.
- Subjects :
- endocrine system
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Fluorescent Antibody Technique
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Islets of Langerhans
Endocrinology
Diabetes mellitus
Internal medicine
Neuropilin 1
Internal Medicine
medicine
Humans
Genetic Predisposition to Disease
Genetic Testing
RNA, Messenger
Age of Onset
Allele
Child
Gene
Alleles
Type 1 diabetes
Chi-Square Distribution
Pancreatic islets
General Medicine
medicine.disease
Neuropilin-1
Diabetes Mellitus, Type 1
medicine.anatomical_structure
embryonic structures
cardiovascular system
sense organs
Pancreas
Subjects
Details
- ISSN :
- 01688227
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Diabetes Research and Clinical Practice
- Accession number :
- edsair.doi.dedup.....14fd524a11ea11b74ca137bdb665d888
- Full Text :
- https://doi.org/10.1016/j.diabres.2009.12.016