The importance of colloid osmotic pressure during open heart surgery in infants

HANEDA, K., SATO, S., ISHIZAWA, E. and HORIUCHI, T. The Importance of Colloid Osmotic Pressure during Open Heart Surgery in Infants. Tohoku J. exp. Med., 1985, 147 (1) 65-71-Fifty-five infants with transposition of the great arteries and with total anomalous pulmonary venous return underwent intracardiac repair under combined surface/perfusion hypothermia and total circulatory arrest in 1975 to 1983. Although cardiopulmonary bypass (CPB) time is limited when hypothermic circulatory arrest is employed, fluid balance derangement is one of the major postoperative complications. Fluid balance at the end of CPB averaged +299.5ml (+63.4ml/kg) when hemodilution with lactated Ringer's was utilized (Group A). Since colloid osmotic pressure (COP) plays an important role in regulating fluid balance, colloid hemodilution prime (whole blood and plasma) was employed in the last 3 years (Group B). COP and total protein concentration during CPB with colloid prime were maintained at around 19mmHg and 5g/100ml, respectively. In Group B, fluid balance at the end of CPB averaged +81.1ml (+16.3ml/kg) and was significantly less than in Group A (p