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Multimodal Brain Changes in First-Episode Mania: A Voxel-Based Morphometry, Functional Magnetic Resonance Imaging, and Connectivity Study
- Source :
- Schizophrenia Bulletin, Goikolea, J M, Dima, D, Landín-Romero, R, Torres, I, DelVecchio, G, Valentí, M, Amann, B L, Bonnín, C M, McKenna, P J, Pomarol-Clotet, E, Frangou, S & Vieta, E 2018, ' Multimodal Brain Changes in First-Episode Mania : A Voxel-Based Morphometry, Functional Magnetic Resonance Imaging, and Connectivity Study ', Schizophrenia Bulletin . https://doi.org/10.1093/schbul/sby047
- Publication Year :
- 2019
-
Abstract
- Background: Brain structural and functional changes in bipolar disorder (BD) are well-established findings, but it is uncertain whether these changes are already present in first episode mania (FEM).Methods: We compared 31 FEM subjects, with 31 healthy individuals matched for age, sex, and premorbid IQ. Whole-brain voxel-wise morphometry, functional magnetic resonance imaging during the n-back task, and a functional connectivity analysis were performed.Results: There were no volumetric differences between the 2 groups. During the 2-back task, FEM patients did not perform differently from controls and activated similar regions, but they showed less deactivation in the ventromedial prefrontal cortex (vmPFC), the anterior hub of the default mode network (DMN). They showed preserved functional connectivity between the vmPFC and other regions of the DMN, but increased connectivity with the superior frontal gyrus.Conclusions: The absence of volumetric changes in FEM patients suggests that these changes could be related to progression of the illness. On the other hand, the failure of deactivation of the anterior hub of the DMN is present from the onset of the illness and may represent a core pathophysiological feature of BD.
- Subjects :
- Adult
Male
Bipolar Disorder
Adolescent
Ventromedial prefrontal cortex
Neuroimaging
Executive Function
Young Adult
03 medical and health sciences
0302 clinical medicine
Connectome
Humans
Medicine
Bipolar disorder
Default mode network
Cerebral Cortex
First episode
medicine.diagnostic_test
business.industry
Voxel-based morphometry
Middle Aged
medicine.disease
Magnetic Resonance Imaging
030227 psychiatry
Psychiatry and Mental health
medicine.anatomical_structure
Superior frontal gyrus
Female
Nerve Net
business
Functional magnetic resonance imaging
Neuroscience
human activities
Psychomotor Performance
030217 neurology & neurosurgery
Regular Articles
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Schizophrenia Bulletin, Goikolea, J M, Dima, D, Landín-Romero, R, Torres, I, DelVecchio, G, Valentí, M, Amann, B L, Bonnín, C M, McKenna, P J, Pomarol-Clotet, E, Frangou, S & Vieta, E 2018, ' Multimodal Brain Changes in First-Episode Mania : A Voxel-Based Morphometry, Functional Magnetic Resonance Imaging, and Connectivity Study ', Schizophrenia Bulletin . https://doi.org/10.1093/schbul/sby047
- Accession number :
- edsair.doi.dedup.....14d289ff38b1fc5068d5444fd535ddae