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Specific Th1 cell lines that confer protective immunity against experimental Borrelia burgdorferi infection in mice
- Source :
- Journal of Leukocyte Biology. 63:542-549
- Publication Year :
- 1998
- Publisher :
- Oxford University Press (OUP), 1998.
-
Abstract
- Although humoral responses to Borrelia burgdorferi (Bb) have been shown to be protective in some animal models of Lyme disease, the role of T cells in this disease is less well understood. This work describes three Bb-specific T cell lines that prevent disease progression in syngeneic mice. The T cell lines were generated in C3H mice immunized with Bb in complete Freund's adjuvant. All lines were Bb-specific, CD4+, TCRαβ+, and they proliferated and produced interferon-γ and interleukin-2 on stimulation with Bb. Injection of the cell lines into naive C3H recipients significantly reduced the number of organisms recoverable from the blood and tissues of infected mice and protected them from developing Bb-induced periarthritis. These studies demonstrated that Th1 cells can confer resistance to Bb infection in susceptible mice and suggested that the timing of this T cell response may be critical for determining disease outcome.
- Subjects :
- Cellular immunity
Adoptive cell transfer
medicine.medical_treatment
T cell
Immunology
Biology
Mice
Borrelia burgdorferi Group
Immunity
medicine
Animals
Immunology and Allergy
Hypersensitivity, Delayed
Borrelia burgdorferi
Immunity, Cellular
Lyme Disease
Mice, Inbred C3H
Arthritis
Borrelia Burgdorferi Infection
Cell Biology
Th1 Cells
biology.organism_classification
Adoptive Transfer
Virology
medicine.anatomical_structure
Cell culture
Female
Adjuvant
Subjects
Details
- ISSN :
- 19383673 and 07415400
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Journal of Leukocyte Biology
- Accession number :
- edsair.doi.dedup.....14a3f84f110d2fb7754e1dc9c68e157a