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Immune Reconstitution of Patients Who Recovered From Steroid-Refractory Acute Graft-Versus-Host Disease After Basiliximab Treatment

Authors :
Dao-Xing, Deng
Shuang, Fan
Xiao-Hui, Zhang
Lan-Ping, Xu
Yu, Wang
Chen-Hua, Yan
Huan, Chen
Yu-Hong, Chen
Wei, Han
Feng-Rong, Wang
Jing-Zhi, Wang
Xu-Ying, Pei
Ying-Jun, Chang
Kai-Yan, Liu
Xiao-Jun, Huang
Xiao-Dong, Mo
Source :
Frontiers in Oncology. 12
Publication Year :
2022
Publisher :
Frontiers Media SA, 2022.

Abstract

We aimed to identify the characteristics of immune reconstitution (IR) in patients who recovered from steroid-refractory acute graft-versus-host disease (SR-aGVHD) after basiliximab treatment. A total of 179, 124, 80, and 92 patients were included in the analysis for IR at 3, 6, 9, and 12 months, respectively, after haploidentical donor hematopoietic stem cell transplantation (HID HSCT). We observed that IR was fastest for monocytes and CD8+ T cells, followed by lymphocytes, CD3+ T cells, and CD19+ B cells and slowest for CD4+ T cells. Almost all immune cell subsets recovered comparably between patients receiving

Subjects

Subjects :
Cancer Research
Oncology

Details

ISSN :
2234943X
Volume :
12
Database :
OpenAIRE
Journal :
Frontiers in Oncology
Accession number :
edsair.doi.dedup.....14a031114ba364599abd9f0e41bed9b9