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Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons
- Source :
- Neuron. 14:717-730
- Publication Year :
- 1995
- Publisher :
- Elsevier BV, 1995.
-
Abstract
- Homozygous Igf1−1− mice at 2 months of age had reduced brain weights, with reductions evenly affecting all major brain areas. The gross morphology of the CNS was normal, but the size of white matter structures in brain and spinal cord was strongly reduced, owing to decreased numbers of axons and oligodendrocytes. Myelinated axons were more strongly reduced in number than unmyelinated axons. The volume of the dentate gyrus granule cell layer was reduced in excess of the decrease in brain weight. Among populations of calcium-binding protein-containing neurons, there was a selective reduction in the number of striatal parvalbumin-containing cells. Numbers of mesencephalic dopaminergic neurons, striatal and basal forebrain cholinergic neurons, and spinal cord motoneurons were unaffected. Cerebellar morphology was unaltered. Our findings suggest cell type- and region-specific functions for IGF-I and emphasize prominent roles in axon growth and maturation in CNS myelination.
- Subjects :
- Calbindins
Neuroscience(all)
Cell Count
Hippocampal formation
Biology
Hippocampus
White matter
Mice
03 medical and health sciences
S100 Calcium Binding Protein G
0302 clinical medicine
Glial Fibrillary Acidic Protein
medicine
Animals
Insulin-Like Growth Factor I
Cholinergic neuron
10. No inequality
Myelin Sheath
030304 developmental biology
Neurons
CNS hypomyelination
0303 health sciences
Basal forebrain
General Neuroscience
Dentate gyrus
Brain
Organ Size
Granule cell
Spinal cord
Axons
Corpus Striatum
Mice, Inbred C57BL
Parvalbumins
medicine.anatomical_structure
Spinal Cord
nervous system
Astrocytes
Calbindin 2
Mutation
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 08966273
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Neuron
- Accession number :
- edsair.doi.dedup.....149fa8184a6bf11d134bc9e500c21289
- Full Text :
- https://doi.org/10.1016/0896-6273(95)90216-3