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Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status
- Source :
- Respiratory medicine, 161:105817. W.B. Saunders Ltd
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Background Asthma prevalence is 339 million globally. ‘Severe asthma’ (SA) comprises subjects with uncontrolled asthma despite proper management. Objectives To compare asthma from diverse ethnicities and environments. Methods A cross-sectional analysis of two adult cohorts, a Brazilian (ProAR) and a European (U-BIOPRED). U-BIOPRED comprised of 311 non-smoking with Severe Asthma (SAn), 110 smokers or ex-smokers with SA (SAs) and 88 mild to moderate asthmatics (MMA) while ProAR included 544 SA and 452 MMA. Although these projects were independent, there were similarities in objectives and methodology, with ProAR adopting operating procedures of U-BIOPRED. Results Among SA subjects, age, weight, proportion of former smokers and FEV1 pre-bronchodilator were similar. The proportion of SA with a positive skin prick tests (SPT) to aeroallergens, the scores of sino-nasal symptoms and quality of life were comparable. In addition, blood eosinophil counts (EOS) and the % of subjects with EOS > 300 cells/μl were not different. The Europeans with SA however, were more severe with a greater proportion of continuous oral corticosteroids (OCS), worse symptoms and more frequent exacerbations. FEV1/FVC pre- and post-bronchodilator were lower among the Europeans. The MMA cohorts were less comparable in control and treatment, but similar in the proportion of allergic rhinitis, gastroesophageal reflux disease and EOS >3%. Conclusions ProAR and U-BIOPRED cohorts, with varying severity, ethnicity and environment have similarities, which provide the basis for global external validation of asthma phenotypes. This should stimulate collaboration between asthma consortia with the aim of understanding SA, which will lead to better management.
- Subjects :
- Male
Cardiac & Cardiovascular Systems
BLOOD
Cross-sectional study
COUNT
Respiratory System
Ethnic group
Disease
Severity of Illness Index
Cohort Studies
0302 clinical medicine
Quality of life
Forced Expiratory Volume
Disease management
Medicine
030212 general & internal medicine
610 Medicine & health
1102 Cardiorespiratory Medicine and Haematology
Middle Aged
PREVALENCE
Europe
Phenotypes
Phenotype
INFECTIONS
Female
Life Sciences & Biomedicine
Brazil
Cohort study
Pulmonary and Respiratory Medicine
Adult
Cross sectional study
U-BIOPRED Study Groups
03 medical and health sciences
FEV1/FVC ratio
ProAR Study Group
Humans
Socioeconomic status
Asthma
Science & Technology
business.industry
1103 Clinical Sciences
medicine.disease
SPIROMETRY
REFERENCE VALUES
respiratory tract diseases
SEVERITY
Cross-Sectional Studies
030228 respiratory system
Social Class
Cardiovascular System & Cardiology
Quality of Life
business
Biomarkers
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 09546111
- Database :
- OpenAIRE
- Journal :
- Respiratory medicine, 161:105817. W.B. Saunders Ltd
- Accession number :
- edsair.doi.dedup.....1491bcad6f32c965a6ad0f8da265e17d