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Diagnostic and Prognostic Significance of Keap1 mRNA Expression for Lung Cancer Based on Microarray and Clinical Information from Oncomine Database
- Source :
- Current Medical Science. 41:597-609
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- We performed a bioinformatics analysis with validation by multiple databases, aiming to evaluate the diagnostic and prognostic value of Kelch-like ECH-associated protein 1 (Keap1) mRNA for lung cancer, and to explore possible mechanisms. Diagnostic performance of Keap1 mRNA was determined by receiver operating characteristic (ROC) curve analysis. Prognostic implication of Keap1 mRNA was estimated by Kaplan-Meier survival analysis. Co-expressed genes with both Keap1 and Nfe2L2 were identified by LinkedOmics. Mechanisms of Keap1-Nfe2L2-co-expressed genes underlying the pathogenesis of lung cancer were explored by function enrichment and pathway analysis. The ROC curve analysis determined a good diagnostic performance of Keap1 mRNA for lung squamous cell carcinoma (LUSC), with an area under the ROC curve (AUC) of 0.833, sensitivity of 72.7%, and specificity of 90.6% (P
- Subjects :
- Male
Microarray
NF-E2-Related Factor 2
Adenocarcinoma of Lung
Kaplan-Meier Estimate
computer.software_genre
Biochemistry
Gene expression
Biomarkers, Tumor
Genetics
medicine
Humans
RNA, Messenger
Lung cancer
Survival analysis
Proportional Hazards Models
Kelch-Like ECH-Associated Protein 1
Database
Receiver operating characteristic
business.industry
Proportional hazards model
Computational Biology
Microarray Analysis
medicine.disease
Progression-Free Survival
NFE2L2
Gene Expression Regulation, Neoplastic
Carcinoma, Squamous Cell
Adenocarcinoma
Female
business
computer
Subjects
Details
- ISSN :
- 2523899X and 20965230
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Current Medical Science
- Accession number :
- edsair.doi.dedup.....148a724d8d09c35c21a8f3e3999837c7